Original Article

Does Hepatic Steatosis Influence the Virological Response with Chronic Hepatitis B Patients Treated with Entecavir or Tenofovir Disoproxil Fumarate?

Volume 33 · Issue 7 Publish Date: July 15, 2022
Roni Atalay Süleyman Sayar Fatma Gülçiçek Ayrancı Şüheda Çakmak İbrahim Halil Tanboğa Levent Doğanay Kamil Özdil
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Published In

Turkish Journal of Gastroenterology

Volume 33 · Issue 7

Pages: 587-595

History

Published Online: July 15, 2022

Copyright © 2022 Roni Atalay, Süleyman Sayar, Fatma Gülçiçek Ayrancı, Şüheda Çakmak, İbrahim Halil Tanboğa, Levent Doğanay, Kamil Özdil

Roni Atalay
Department of Gastroenterology, Yıldırım Beyazıt University, Ankara Atatürk Education and Research Hospital, Ankara, Turkey
Süleyman Sayar
Health Sience University, Umraniye Research And Education Hospital-Gastroenterology
Fatma Gülçiçek Ayrancı
Department of Pathology, Ümraniye Teaching and Research Hospital, University of Health Sciences, İstanbul, Turkey
Şüheda Çakmak
Department of Internal Medicine, Ümraniye Teaching and Research Hospital, University of Health Sciences, İstanbul, Turkey
İbrahim Halil Tanboğa
Department of Biostatistics, Nişantaşı University, İstanbul, Turkey
Levent Doğanay
Department of Gastroenterology, University of Health Sciences Ümraniye Training and Research Hospital, İstanbul, Turkey
Kamil Özdil
Department of Gastroenterology, Ümraniye Training and Research Hospital, İstanbul
Atalay, R., Sayar, S., Ayrancı, F. G., Çakmak, Şüheda, Tanboğa, İbrahim H., Doğanay, L., & Özdil, K. (2022). Does Hepatic Steatosis Influence the Virological Response with Chronic Hepatitis B Patients Treated with Entecavir or Tenofovir Disoproxil Fumarate?. Turkish Journal of Gastroenterology, 33(7), 587–595. https://doi.org/10.5152/tjg.2022.21051
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Abstract

Background: The effect of hepatic steatosis on the response to antiviral therapy administered in chronic hepatitis B patients is yet to be clarified. In this study, our aim was to determine the effect of hepatic steatosis on the virological response in chronic hepatitis B patients who were treated with entecavir or tenofovir disoproxil fumarate. Methods: This retrospective cohort study was performed using the data of liver biopsy-proven chronic hepatitis B patients with or without hepatic steatosis, who received entecavir or tenofovir disoproxil fumarate treatment between 2012 and 2017. The undetectable serum hepatitis B virus deoxyribonucleic acid level under treatment was defined as the complete virological response. The predictors of virological response were determined, and it was checked whether the virological response was affected by hepatic steatosis in chronic hepatitis B patients who have undergone entecavir or tenofovir disoproxil fumarate treatment. Results: A total of 324 chronic hepatitis B patients, of which 203 (63%) were males, were included in the study. The median age of the patients was 42 years (range: 35-51 years). Hepatic steatosis was observed in 25% of the patients, and steatohepatitis in 4%. The median time to complete virological response was found to be 6 months (range: 3-9 months). In the full analysis model, the log hepatitis B virus deoxyribonucleic acid was determined as the factor most associated with virological response (P < .001). No statistically signifi- cant relationship was detected between hepatic steatosis and virological response (P = .409). Conclusion: Concomitant hepatic steatosis has no significant impact on the virological response in chronic hepatitis B patients who have undergone entecavir or tenofovir disoproxil fumarate treatment. Cite this article as: Atalay R, Sayar S, Gülçiçek Ayrancı F, et al. Does hepatic steatosis influence the virological response with chronic hepatitis B patients treated with entecavir or tenofovir disoproxil fumarate? Turk J Gastroenterol. 2022;33(7):587-595.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 33 · Issue 7
Pages 587-595
DOI 10.5152/tjg.2022.21051
History
Published Online July 15, 2022
Copyright
Copyright (c) 2022 Roni Atalay, Süleyman Sayar, Fatma Gülçiçek Ayrancı, Şüheda Çakmak, İbrahim Halil Tanboğa, Levent Doğanay, Kamil Özdil
Affiliations
Roni Atalay
Department of Gastroenterology, Yıldırım Beyazıt University, Ankara Atatürk Education and Research Hospital, Ankara, Turkey
Süleyman Sayar
Health Sience University, Umraniye Research And Education Hospital-Gastroenterology
Fatma Gülçiçek Ayrancı
Department of Pathology, Ümraniye Teaching and Research Hospital, University of Health Sciences, İstanbul, Turkey
Şüheda Çakmak
Department of Internal Medicine, Ümraniye Teaching and Research Hospital, University of Health Sciences, İstanbul, Turkey
İbrahim Halil Tanboğa
Department of Biostatistics, Nişantaşı University, İstanbul, Turkey
Levent Doğanay
Department of Gastroenterology, University of Health Sciences Ümraniye Training and Research Hospital, İstanbul, Turkey
Kamil Özdil
Department of Gastroenterology, Ümraniye Training and Research Hospital, İstanbul
Cite this Article
Atalay, R., Sayar, S., Ayrancı, F. G., Çakmak, Şüheda, Tanboğa, İbrahim H., Doğanay, L., & Özdil, K. (2022). Does Hepatic Steatosis Influence the Virological Response with Chronic Hepatitis B Patients Treated with Entecavir or Tenofovir Disoproxil Fumarate?. Turkish Journal of Gastroenterology, 33(7), 587–595. https://doi.org/10.5152/tjg.2022.21051
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