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Effects of Long-Term Tenofovir and Entecavir Treatment on Bone Mineral Density in Patients with Chronic Hepatitis B

Volume 33 · Issue 1 Publish Date: January 15, 2022
Resul Kahraman Abdurrahman Şahin Oğuzhan Öztürk Turan Çalhan Süleyman Sayar Evren Kanat Levent Doğanay Kamil Özdil
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Turkish Journal of Gastroenterology

Volume 33 · Issue 1

Pages: 35-43

History

Published Online: January 15, 2022

Copyright © 2022 Resul Kahraman, Abdurrahman Şahin, Oğuzhan Öztürk, Turan Çalhan, Süleyman Sayar, Evren Kanat, Levent Doğanay, Kamil Özdil

Resul Kahraman
Health Sience University, Umraniye Research And Education Hospital-Gastroenterology
Abdurrahman Şahin
Department of Gastroenterology, Fırat University School of Medicine, Elazığ, Turkey
Oğuzhan Öztürk
Health Sience University, Umraniye Research And Education Hospital-Gastroenterology
Turan Çalhan
Department of Gastroenterology, Health Science University, Ümraniye Training and Research Hospital, İstanbul, Turkey
Süleyman Sayar
Health Sience University, Umraniye Research And Education Hospital-Gastroenterology
Evren Kanat
Department of Gastroenterology, Health Science University, Umraniye Training and Research Hospital, Istanbul, Turkey
Levent Doğanay
Department of Gastroenterology, University of Health Sciences Ümraniye Training and Research Hospital, İstanbul, Turkey
Kamil Özdil
Department of Gastroenterology, Ümraniye Training and Research Hospital, İstanbul
Kahraman, R., Şahin, A., Öztürk, O., Çalhan, T., Sayar, S., Kanat, E., … Özdil, K. (2022). Effects of Long-Term Tenofovir and Entecavir Treatment on Bone Mineral Density in Patients with Chronic Hepatitis B. Turkish Journal of Gastroenterology, 33(1), 35–43. https://doi.org/10.5152/tjg.2020.18024
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Abstract

Background: We aimed to investigate the long-term effects of tenofovir disoproxil fumarate and entecavir treatment on bone mineral density and evaluated the fracture risk assessment tool score in patients with chronic hepatitis B. Methods: A total of 58 chronic hepatitis B patients treated with tenofovir disoproxil fumarate (n = 40) and entecavir (n = 18) were included in this prospective study from 2012 to 2016. To evaluate bone mineral density, dual-X-ray absorptiometry, fracture risk assessment tool, and laboratory examinations were performed in all patients first at baseline and second at the end of the study. Results: Age, sex, body mass index, fibrosis score, and viral load were similar in both groups. The mean follow-up was 33 months in the tenofovir disoproxil fumarate group and 31 months in the entecavir group. In patients treated with entecavir, there was no statistically significant difference between baseline and second bone mineral density including lumbar spine (L) and total hip T score. In patients treated with tenofovir disoproxil fumarate, there was a significant difference in the second bone mineral density compared with baseline bone mineral density for L3 (P = .033) and the major fracture risk assessment tool score (P = .03). When patients were divided into 3 groups (normal bone mineral density, osteopenic, and osteoporotic), there was a significant increase in the number of osteopenic patients in the total hip T score after tenofovir disoproxil fumarate treatment (P = .034). Conclusion: Our results suggest a decrease in the bone mineral density for lumbar spine (L3), an increase in the number of patients with hip osteopenia, and major fracture risk assessment tool score after long-term tenofovir disoproxil fumarate treatment in patients with rechronic hepatitis B.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 33 · Issue 1
Pages 35-43
DOI 10.5152/tjg.2020.18024
History
Published Online January 15, 2022
Copyright
Copyright (c) 2022 Resul Kahraman, Abdurrahman Şahin, Oğuzhan Öztürk, Turan Çalhan, Süleyman Sayar, Evren Kanat, Levent Doğanay, Kamil Özdil
Affiliations
Resul Kahraman
Health Sience University, Umraniye Research And Education Hospital-Gastroenterology
Abdurrahman Şahin
Department of Gastroenterology, Fırat University School of Medicine, Elazığ, Turkey
Oğuzhan Öztürk
Health Sience University, Umraniye Research And Education Hospital-Gastroenterology
Turan Çalhan
Department of Gastroenterology, Health Science University, Ümraniye Training and Research Hospital, İstanbul, Turkey
Süleyman Sayar
Health Sience University, Umraniye Research And Education Hospital-Gastroenterology
Evren Kanat
Department of Gastroenterology, Health Science University, Umraniye Training and Research Hospital, Istanbul, Turkey
Levent Doğanay
Department of Gastroenterology, University of Health Sciences Ümraniye Training and Research Hospital, İstanbul, Turkey
Kamil Özdil
Department of Gastroenterology, Ümraniye Training and Research Hospital, İstanbul
Cite this Article
Kahraman, R., Şahin, A., Öztürk, O., Çalhan, T., Sayar, S., Kanat, E., … Özdil, K. (2022). Effects of Long-Term Tenofovir and Entecavir Treatment on Bone Mineral Density in Patients with Chronic Hepatitis B. Turkish Journal of Gastroenterology, 33(1), 35–43. https://doi.org/10.5152/tjg.2020.18024
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