Published In
Turkish Journal of Gastroenterology
Volume 36 · Issue 12
Pages: 822-833
History
Published Online: June 23, 2025
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright © 2025 Muhammed Bahaddin Durak, Yasir Furkan Cagin, Ayhan Balkan, Yusuf Coskun, Tarkan Karakan, Yavuz Cagir, Yavuz Beyazit, Ali Atay, Ali Can Erdem, Guray Can, Engin Altinkaya, Hakan Dursun, Orhan Coskun, Mehmet Rasit Ayte, Mevlut Hamamci, Ilyas Tenlik, Cem Simsek, Abdurrahman Sahin, Huseyin Koseoglu, Mustafa Akar, Kenan Kosar, Bulent Albayrak, Eylem Karatay, Murat Kekilli, Mehmet Asil, Hilmi Ataseven, Mehmet Cindoruk, Ilhami Yuksel
Muhammed Bahaddin Durak
Department of Gastroenterology, Hacettepe University Faculty of Medicine, Ankara, Türkiye
Yasir Furkan Cagin
Department of Gastroentrology, Malatya Turgut Özal University Faculty of Medicine, Malatya, Türkiye
Ayhan Balkan
Department of Gastroenterology, Gaziantep University Faculty of Medicine, Gaziantep, Türkiye
Yusuf Coskun
Department of Gastroenterology, Etlik City Hospital, Ankara, Türkiye
Tarkan Karakan
Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Türkiye
Yavuz Cagir
Department of Gastroenterology, Yenimahalle Training and Research Hospital, Ankara Yıldırım Beyazıt University, Ankara, Türkiye
Yavuz Beyazit
Department of Gastroenterology, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Türkiye
Ali Atay
Department of Gastroenterology, Ankara Bilkent City Hospital, Ankara, Türkiye
Ali Can Erdem
Department of Gastroenterology, Necmettin Erbakan University Faculty of Medicine, Konya, Türkiye
Guray Can
Department of Gastroenterology, Doruk Nilüfer Hospital, Bursa, Türkiye
Engin Altinkaya
Department of Gastroenterology, Cumhuriyet University Faculty of Medicine, Sivas, Türkiye
Hakan Dursun
Department of Gastroenterology, Atatürk University Faculty of Medicine, Erzurum, Türkiye
Orhan Coskun
Department of Gastroenterology, Ankara Bilkent City Hospital, Ankara, Türkiye
Mehmet Rasit Ayte
Department of Gastroenterology, Ankara Atatürk Sanatoryum Education and Research Hospital, Ankara, Türkiye
Mevlut Hamamci
Department of Gastroenterology, Ankara Bilkent City Hospital, Ankara, Türkiye
Ilyas Tenlik
Department of Gastroenterology, Ankara Bilkent City Hospital, Ankara, Türkiye
Cem Simsek
Department of Gastroenterology, Hacettepe University Faculty of Medicine, Ankara, Türkiye
Abdurrahman Sahin
Department of Gastroenterology, Tokat Gaziosmanpaşa University Faculty of Medicine, Tokat, Türkiye
Huseyin Koseoglu
Department of Gastroenterology, Hitit University Faculty of Medicine, Çorum, Türkiye
Mustafa Akar
Department of Gastroenterology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Türkiye
Kenan Kosar
Department of Gastroenterology, Karabük Education and Research Hospital, Karabük, Türkiye
Bulent Albayrak
Department of Gastroenterology, Atatürk Education and Research Hospital, Erzurum, Türkiye
Eylem Karatay
Department of Internal Medicine, İstinye University Faculty of Medicine, İstanbul, Türkiye
Murat Kekilli
Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Türkiye
Mehmet Asil
Department of Gastroenterology, Necmettin Erbakan University Faculty of Medicine, Konya, Türkiye
Hilmi Ataseven
Department of Gastroenterology, Cumhuriyet University Faculty of Medicine, Sivas, Türkiye
Mehmet Cindoruk
Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Türkiye
Ilhami Yuksel
Department of Gastroenterology, Ankara Bilkent City Hospital, Ankara, Türkiye,Department of Gastroenterology, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Türkiye
Durak, M. B., Cagin, Y. F., Balkan, A., Coskun, Y., Karakan, T., Cagir, Y., … Yuksel, I. (2025). Three-Decade Analysis of Inflammatory Bowel Disease in Türkiye: A Multicenter Study (1993-2024). Turkish Journal of Gastroenterology, 36(12), 822–833. https://doi.org/10.5152/tjg.2025.25063
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Abstract
Background/Aims: Inflammatory bowel diseases (IBDs) are increasingly prevalent and challenging globally. Data regarding IBD frequency and severity between Europe and Asia are needed. The aim was to investigate the trend of IBD in Türkiye during the last 3 decades.
Materials and Methods: The study was conducted retrospectively at 14 centers in Türkiye between June 1993 and March 2024.
Results: Over 30 years, 4308 patients, of whom 2507 (58.2%) had ulcerative colitis (UC) and 1717 (39.9%) had Crohn’s Disease (CD), were included in the study. The overall median age at the onset of IBD was 34.43 (25.28-45.64) years; the age at onset of IBD was younger in CD compared to UC (32.72 vs. 35.52 years respectively, P < .001). The peak age onset range was 28-32 years in CD, whereas 23-27 years in UC. Overall, 2526 (58.6%) patients were male. The most common location was left-sided colitis in UC patients (45.1%), followed by extensive colitis (31.2%), and proctitis (23.7%), while ileal involvement in CD patients (45.2%), afterward ileocolonic (409%), and colonic (13.5%). Both illnesses are becoming increasingly prevalent. The UC/CD ratio tends to decrease over time. During the study period, 1577 (36.6%) patients received biologic treatment. During the study period, 418 (24.3%) underwent resective surgery for CD and 88 (3.5%) total colectomy for UC; the major abdominal surgery has declined over time.
Conclusion: The frequency and characteristic features of IBD in Türkiye appear to be between Europe and Asia. Over time, while the usage of biologic therapy and the rate of CD have increased, the frequency of surgery has decreased.
Cite this article as: Durak MB, Cagin YF, Balkan A, et al. Three-decade analysis of inflammatory bowel disease in Türkiye: A multicenter study (1993-2024). Turk J Gastroenterol. 2025;36(12):822-833.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 36 · Issue 12
Pages
822-833
History
Published Online
June 23, 2025
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright
Copyright (c) 2025 Muhammed Bahaddin Durak, Yasir Furkan Cagin, Ayhan Balkan, Yusuf Coskun, Tarkan Karakan, Yavuz Cagir, Yavuz Beyazit, Ali Atay, Ali Can Erdem, Guray Can, Engin Altinkaya, Hakan Dursun, Orhan Coskun, Mehmet Rasit Ayte, Mevlut Hamamci, Ilyas Tenlik, Cem Simsek, Abdurrahman Sahin, Huseyin Koseoglu, Mustafa Akar, Kenan Kosar, Bulent Albayrak, Eylem Karatay, Murat Kekilli, Mehmet Asil, Hilmi Ataseven, Mehmet Cindoruk, Ilhami Yuksel
Affiliations
Muhammed Bahaddin Durak
Department of Gastroenterology, Hacettepe University Faculty of Medicine, Ankara, Türkiye
Yasir Furkan Cagin
Department of Gastroentrology, Malatya Turgut Özal University Faculty of Medicine, Malatya, Türkiye
Ayhan Balkan
Department of Gastroenterology, Gaziantep University Faculty of Medicine, Gaziantep, Türkiye
Yusuf Coskun
Department of Gastroenterology, Etlik City Hospital, Ankara, Türkiye
Tarkan Karakan
Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Türkiye
Yavuz Cagir
Department of Gastroenterology, Yenimahalle Training and Research Hospital, Ankara Yıldırım Beyazıt University, Ankara, Türkiye
Yavuz Beyazit
Department of Gastroenterology, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Türkiye
Ali Atay
Department of Gastroenterology, Ankara Bilkent City Hospital, Ankara, Türkiye
Ali Can Erdem
Department of Gastroenterology, Necmettin Erbakan University Faculty of Medicine, Konya, Türkiye
Guray Can
Department of Gastroenterology, Doruk Nilüfer Hospital, Bursa, Türkiye
Engin Altinkaya
Department of Gastroenterology, Cumhuriyet University Faculty of Medicine, Sivas, Türkiye
Hakan Dursun
Department of Gastroenterology, Atatürk University Faculty of Medicine, Erzurum, Türkiye
Orhan Coskun
Department of Gastroenterology, Ankara Bilkent City Hospital, Ankara, Türkiye
Mehmet Rasit Ayte
Department of Gastroenterology, Ankara Atatürk Sanatoryum Education and Research Hospital, Ankara, Türkiye
Mevlut Hamamci
Department of Gastroenterology, Ankara Bilkent City Hospital, Ankara, Türkiye
Ilyas Tenlik
Department of Gastroenterology, Ankara Bilkent City Hospital, Ankara, Türkiye
Cem Simsek
Department of Gastroenterology, Hacettepe University Faculty of Medicine, Ankara, Türkiye
Abdurrahman Sahin
Department of Gastroenterology, Tokat Gaziosmanpaşa University Faculty of Medicine, Tokat, Türkiye
Huseyin Koseoglu
Department of Gastroenterology, Hitit University Faculty of Medicine, Çorum, Türkiye
Mustafa Akar
Department of Gastroenterology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Türkiye
Kenan Kosar
Department of Gastroenterology, Karabük Education and Research Hospital, Karabük, Türkiye
Bulent Albayrak
Department of Gastroenterology, Atatürk Education and Research Hospital, Erzurum, Türkiye
Eylem Karatay
Department of Internal Medicine, İstinye University Faculty of Medicine, İstanbul, Türkiye
Murat Kekilli
Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Türkiye
Mehmet Asil
Department of Gastroenterology, Necmettin Erbakan University Faculty of Medicine, Konya, Türkiye
Hilmi Ataseven
Department of Gastroenterology, Cumhuriyet University Faculty of Medicine, Sivas, Türkiye
Mehmet Cindoruk
Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Türkiye
Ilhami Yuksel
Department of Gastroenterology, Ankara Bilkent City Hospital, Ankara, Türkiye,Department of Gastroenterology, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Türkiye
Cite this Article
Durak, M. B., Cagin, Y. F., Balkan, A., Coskun, Y., Karakan, T., Cagir, Y., … Yuksel, I. (2025). Three-Decade Analysis of Inflammatory Bowel Disease in Türkiye: A Multicenter Study (1993-2024). Turkish Journal of Gastroenterology, 36(12), 822–833. https://doi.org/10.5152/tjg.2025.25063
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