Original Article

Molecular characteristics of colorectal hyperplastic polyp subgroups

Volume 31 · Issue 8 · August 2020 Publish Date: August 15, 2020
Mehtat Ünlü 1 Evren Uzun 2 Göksel Bengi 3 Özgül Sağol 4 Sülen Sarıoğlu 5
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Turkish Journal of Gastroenterology

Volume 31 · Issue 8 · August 2020

Pages: 573-580

History

Published Online: August 15, 2020

Copyright © 2020 Mehtat Ünlü, Evren Uzun, Göksel Bengi, Özgül Sağol, Sülen Sarıoğlu

Mehtat Ünlü
Department of Pathology, Dokuz Eylül University School of Medicine, İzmir, Turkey
Evren Uzun
Department of Pathology, Dokuz Eylül University School of Medicine, İzmir, Turkey
Göksel Bengi
Department of Gastroenterology, Dokuz Eylül University, School of Medicine, ?zmir
Özgül Sağol
Departments of Pathology, Dokuz Eylül University, School of Medicine, İzmir
Sülen Sarıoğlu
Departments of Pathology, Dokuz Eylül University, School of Medicine, İzmir
Ünlü, M., Uzun, E., Bengi, G., Sağol, Özgül, & Sarıoğlu, S. (2020). Molecular characteristics of colorectal hyperplastic polyp subgroups. Turkish Journal of Gastroenterology, 31(8), 573–580. https://doi.org/10.5152/tjg.2020.19322
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Abstract

Background/Aims: The importance of hyperplastic polyps during colorectal carcinogenesis is appreciated related to the understanding of serrated pathway. The morphologic subtypes of hyperplastic polyps in carcinogenesis and the nomenculature of lesions with both hyperplastic and adenomatous areas are controversial. We aimed to reveal the molecular properties of hyperplastic polyp subtypes and the molecular changes in polyps containing both hyperplastic and adenomatous areas. Matherial and Methods: 49 hyperplastic polyps [19 microvesicular (MVHP), 19 goblet-rich (GRHP), 11 mucin-poor (MPHP)] and 10 mixed hyperplastic and adenomatous polyps were analysed for KRAS, BRAF mutations and MSI with real-time PCR. Results: 68,4% of MVHPs and 81% of MPHPs which were localized in right colon had BRAF mutations. While none of the GRHPs showing a KRAS mutation with a rate of 73% was localized in the ascending colon, 63% of them were localized in the rectosigmoid area. In five (50%) of the mixed polyps, KRAS mutation was detected both in the hyperplastic and adenoma components. There was no BRAF mutation in any of the mixed polyps. However, in two cases, the hyperplastic component was MSI-H and the adenoma area was MSS. Conclusion: Hyperplastic polyps, even if smaller than 5 mm, are precancerous lesions bearing different mutations. GRHPs with predominant KRAS mutations and MVHPs and MPHSs with predominant BRAF mutations are precancerous. Although the molecular investigations for HPP/SP are not necessary the morphological subtyping should be included if the case is diagnosed with HPP/SP as it will be useful for attracting the gastroenterologist’s attention.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 31 · Issue 8 · August 2020
Pages 573-580
DOI 10.5152/tjg.2020.19322
History
Published Online August 15, 2020
Copyright
Copyright (c) 2020 Mehtat Ünlü, Evren Uzun, Göksel Bengi, Özgül Sağol, Sülen Sarıoğlu
Affiliations
1
Mehtat Ünlü
Department of Pathology, Dokuz Eylül University School of Medicine, İzmir, Turkey
2
Evren Uzun
Department of Pathology, Dokuz Eylül University School of Medicine, İzmir, Turkey
3
Göksel Bengi
Department of Gastroenterology, Dokuz Eylül University, School of Medicine, ?zmir
4
Özgül Sağol
Departments of Pathology, Dokuz Eylül University, School of Medicine, İzmir
5
Sülen Sarıoğlu
Departments of Pathology, Dokuz Eylül University, School of Medicine, İzmir
Cite this Article
Ünlü, M., Uzun, E., Bengi, G., Sağol, Özgül, & Sarıoğlu, S. (2020). Molecular characteristics of colorectal hyperplastic polyp subgroups. Turkish Journal of Gastroenterology, 31(8), 573–580. https://doi.org/10.5152/tjg.2020.19322
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