Original Articles

Clinical Features and Prevalence of Osteosarcopenia in Chronic Pancreatitis

Volume 36 · Issue 10 · October 2025 Publish Date: May 5, 2025
Hüseyin Döngelli 1 ORCID Göksel Bengi 2 ORCID Raif Can Yarol 3 ORCID Canan Altay 4 ORCID Süleyman Dolu 5 ORCID Nilay Danış 6 ORCID Ömer Selahattin Topalak 7 ORCID Hale Akpınar 8 ORCID Servet Kızıldağ 9 ORCID Müjde Soytürk 10 ORCID
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Turkish Journal of Gastroenterology

Volume 36 · Issue 10 · October 2025

Pages: 669-679

History

Published Online: May 5, 2025

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2025 Hüseyin Döngelli, Göksel Bengi, Raif Can Yarol, Canan Altay, Süleyman Dolu, Nilay Danış, Ömer Selahattin Topalak, Hale Akpınar, Servet Kızıldağ, Müjde Soytürk

Hüseyin Döngelli ORCID
Department of Internal Medicine, Dokuz Eylül University Hospital, İzmir, Türkiye
Göksel Bengi ORCID
Department of Gastroenterology, Dokuz Eylül University Hospital, İzmir, Türkiye
Raif Can Yarol ORCID
Department of Radiology, Dokuz Eylül University Hospital, İzmir, Türkiye
Canan Altay ORCID
Department of Radiology, Dokuz Eylül University Hospital, İzmir, Türkiye
Süleyman Dolu ORCID
Department of Gastroenterology, Dokuz Eylül University Hospital, İzmir, Türkiye
Nilay Danış ORCID
Department of Gastroenterology, Dokuz Eylül University Hospital, İzmir, Türkiye
Ömer Selahattin Topalak ORCID
Department of Gastroenterology, Dokuz Eylül University Hospital, İzmir, Türkiye
Hale Akpınar ORCID
Department of Gastroenterology, Dokuz Eylül University Hospital, İzmir, Türkiye
Servet Kızıldağ ORCID
Department of Medical Services and Techniques, Dokuz Eylül University Hospital, İzmir, Türkiye
Müjde Soytürk ORCID
Department of Gastroenterology, Dokuz Eylül University Hospital, İzmir, Türkiye
Döngelli, H., Bengi, G., Yarol, R. C., Altay, C., Dolu, S., Danış, N., … Soytürk, M. (2025). Clinical Features and Prevalence of Osteosarcopenia in Chronic Pancreatitis. Turkish Journal of Gastroenterology, 36(10), 669–679. https://doi.org/10.5152/tjg.2025.24664
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Abstract

Background/Aims: The prevalence of sarcopenia and osteopenia/osteoporosis is increased in chronic pancreatitis (CP). This study aims to evaluate the prevalence and related factors of osteosarcopenia in CP patients.

Materials and Methods: Eighty-three CP patients were included in this cross-sectional observational study. Sarcopenia was assessed by measuring the surface area of the paravertebral muscles at the third lumbar region. Pancreatic fecal elastase (PFE) tests evaluated exocrine pancreatic insufficiency (EPI), while dual-energy x-ray absorptiometry scans assessed osteopenia/osteoporosis. EORTC PAN26 and a symptom questionnaire were administered, alongside nutritional marker assessments concurrent with PFE.

Results: The prevalence of sarcopenia and osteopenia/osteoporosis was found to be 22.9% (n = 19) and 68.7% (n = 44), respectively. Factors associated with sarcopenia included male gender (OR: 4.9, P = .044), severe EPI (OR: 4.2, P = .043), smoking (OR: 4.6, P = .040), and zinc deficiency (OR: 2.2, P = .029). Severe EPI was significantly associated with osteopenia/osteoporosis (P = .010), diabetes mellitus (P = .001), sarcopenia (P = .016), and zinc deficiency (P = .012). Individuals with osteoporosis had higher PAN26 scores (P = .029). Factors independently associated with osteopenia/osteoporosis included female gender (OR: 7.8, P = .004), severe EPI (OR: 8.1, P = .003), and sarcopenia (OR: 5, P = .037). The prevalence of osteosarcopenia was 19.2%.

Conclusion: Osteosarcopenia is common in CP patients. Smoking, zinc deficiency, EPI, and male gender are strongly associated with sarcopenia. Screening for osteosarcopenia is essential in CP patients to facilitate appropriate interventions.

 

Cite this article as: Döngelli H, Bengi G, Yarol RC, et al. Clinical features and prevalence of osteosarcopenia in chronic pancreatitis. Turk J Gastroenterol. 2025;36(10):669-679.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 36 · Issue 10 · October 2025
Pages 669-679
DOI 10.5152/tjg.2025.24664
History
Published Online May 5, 2025
License
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright
Copyright (c) 2025 Hüseyin Döngelli, Göksel Bengi, Raif Can Yarol, Canan Altay, Süleyman Dolu, Nilay Danış, Ömer Selahattin Topalak, Hale Akpınar, Servet Kızıldağ, Müjde Soytürk
Affiliations
1
Hüseyin Döngelli ORCID
Department of Internal Medicine, Dokuz Eylül University Hospital, İzmir, Türkiye
2
Göksel Bengi ORCID
Department of Gastroenterology, Dokuz Eylül University Hospital, İzmir, Türkiye
3
Raif Can Yarol ORCID
Department of Radiology, Dokuz Eylül University Hospital, İzmir, Türkiye
4
Canan Altay ORCID
Department of Radiology, Dokuz Eylül University Hospital, İzmir, Türkiye
5
Süleyman Dolu ORCID
Department of Gastroenterology, Dokuz Eylül University Hospital, İzmir, Türkiye
6
Nilay Danış ORCID
Department of Gastroenterology, Dokuz Eylül University Hospital, İzmir, Türkiye
7
Ömer Selahattin Topalak ORCID
Department of Gastroenterology, Dokuz Eylül University Hospital, İzmir, Türkiye
8
Hale Akpınar ORCID
Department of Gastroenterology, Dokuz Eylül University Hospital, İzmir, Türkiye
9
Servet Kızıldağ ORCID
Department of Medical Services and Techniques, Dokuz Eylül University Hospital, İzmir, Türkiye
10
Müjde Soytürk ORCID
Department of Gastroenterology, Dokuz Eylül University Hospital, İzmir, Türkiye
Cite this Article
Döngelli, H., Bengi, G., Yarol, R. C., Altay, C., Dolu, S., Danış, N., … Soytürk, M. (2025). Clinical Features and Prevalence of Osteosarcopenia in Chronic Pancreatitis. Turkish Journal of Gastroenterology, 36(10), 669–679. https://doi.org/10.5152/tjg.2025.24664
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