Original Article

HER2 Status in Gastric and Gastroesophageal Carcinomas: Evaluation of Histopathological Fingings, Paired Resection Biopsy Specimens, and the Effect of Neoadjuvant Therapy: A Single Center Study*

Volume 36 · Issue 6 Publish Date: January 13, 2025
Resmiye Irmak Yuzuguldu ORCID Ozgul Sagol ORCID Mehtat Unlu ORCID Merve Keskinkilic ORCID Serhan Derici ORCID Hale Akpinar ORCID Sulen Sarioglu ORCID
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Published In

Turkish Journal of Gastroenterology

Volume 36 · Issue 6

Pages: 357-370

History

Published Online: January 13, 2025

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2025 Resmiye Irmak Yuzuguldu, Ozgul Sagol, Mehtat Unlu, Merve Keskinkilic, Serhan Derici, Hale Akpinar, Sulen Sarioglu

Resmiye Irmak Yuzuguldu ORCID
Department of Medical Pathology, Dokuz Eylül University Faculty of Medicine, !zmir, Türkiye
Ozgul Sagol ORCID
Department of Medical Pathology, Dokuz Eylül University Faculty of Medicine, !zmir, Türkiye
Mehtat Unlu ORCID
Department of Medical Pathology, Dokuz Eylül University Faculty of Medicine, !zmir, Türkiye
Merve Keskinkilic ORCID
Division of Medical Oncology, Department of Internal Medicine, Dokuz Eylül University Faculty of Medicine, !zmir, Türkiye
Serhan Derici ORCID
Department of General Surgery, Dokuz Eylül University Faculty of Medicine, !zmir, Türkiye
Hale Akpinar ORCID
Division of Gastroenterohepatology, Department of Internal Medicine, Dokuz Eylül University Faculty of Medicine, !zmir, Türkiye
Sulen Sarioglu ORCID
Department of Medical Pathology, Dokuz Eylül University Faculty of Medicine, !zmir, Türkiye
Yuzuguldu, R. I., Sagol, O., Unlu, M., Keskinkilic, M., Derici, S., Akpinar, H., & Sarioglu, S. (2025). HER2 Status in Gastric and Gastroesophageal Carcinomas: Evaluation of Histopathological Fingings, Paired Resection Biopsy Specimens, and the Effect of Neoadjuvant Therapy: A Single Center Study*. Turkish Journal of Gastroenterology, 36(6), 357–370. https://doi.org/10.5152/tjg.2025.24488
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Abstract

Background/Aims: Accurately determining the human epidermal growth factor receptor 2 (HER2) status is crucial in identifying suitable candidates for targeted therapy in gastric cancer, considering the cost and potential side effects of anti-HER2 treatments. This study aimed to assess HER2 overexpression/amplification prevalence in gastric and gastroesophageal cancer patients, its correlation with clinicopathological characteristics, and the consistency of HER2 status between biopsy and radical specimens.

Materials and Methods: We analyzed data from 667 specimens of 600 gastric/gastroesophageal cancer patients at Dokuz Eylül
University Faculty of Medicine from 2012 to 2021. The correlation of HER2 expression and amplification status and clinicopathological
parameters were assessed. Furthermore, we compared HER2 status concordance between paired biopsy-radical specimens when both endoscopic and radical materials were present. Additionally, we compared HER2 status before and after treatment in patients receiving neoadjuvant chemotherapy.

Results: In our study, +3 HER2 immunohistochemistry results were more common in gastroesophageal junction tumors (23%). Human epidermal growth factor receptor 2 immunohistochemistry positivity and HER2 gene amplification were found to be significantly more common in males, people over 65 years of age, and intestinal morphology. Overall concordance of HER2 status between radical and biopsy materials was 95.5%.

Conclusion: The high HER2 concordance between the paired biopsy and radical samples holds significant importance in clinical man
agement. This finding is particularly noteworthy since the HER2 assessment can generally be conducted on small/limited biopsy materi als in routine practice. Our study is the most extensive series from Türkiye and the Balkans, which will shed light on our country’s data by investigating the relationship of HER2 with clinicopathological parameters in gastric/gastroesophageal carcinomas.

 

Cite this article as: Yuzuguldu RI, Sagol O, Unlu M, et al. HER2 status in gastric and gastroesophageal carcinomas: evaluation of histopathological findings, paired resection biopsy specimens, and the effect of neoadjuvant therapy: A single center study. Turk J Gastroenterol. 2025;36(6):357-370.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 36 · Issue 6
Pages 357-370
DOI 10.5152/tjg.2025.24488
History
Published Online January 13, 2025
License
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright
Copyright (c) 2025 Resmiye Irmak Yuzuguldu, Ozgul Sagol, Mehtat Unlu, Merve Keskinkilic, Serhan Derici, Hale Akpinar, Sulen Sarioglu
Affiliations
Resmiye Irmak Yuzuguldu ORCID
Department of Medical Pathology, Dokuz Eylül University Faculty of Medicine, !zmir, Türkiye
Ozgul Sagol ORCID
Department of Medical Pathology, Dokuz Eylül University Faculty of Medicine, !zmir, Türkiye
Mehtat Unlu ORCID
Department of Medical Pathology, Dokuz Eylül University Faculty of Medicine, !zmir, Türkiye
Merve Keskinkilic ORCID
Division of Medical Oncology, Department of Internal Medicine, Dokuz Eylül University Faculty of Medicine, !zmir, Türkiye
Serhan Derici ORCID
Department of General Surgery, Dokuz Eylül University Faculty of Medicine, !zmir, Türkiye
Hale Akpinar ORCID
Division of Gastroenterohepatology, Department of Internal Medicine, Dokuz Eylül University Faculty of Medicine, !zmir, Türkiye
Sulen Sarioglu ORCID
Department of Medical Pathology, Dokuz Eylül University Faculty of Medicine, !zmir, Türkiye
Cite this Article
Yuzuguldu, R. I., Sagol, O., Unlu, M., Keskinkilic, M., Derici, S., Akpinar, H., & Sarioglu, S. (2025). HER2 Status in Gastric and Gastroesophageal Carcinomas: Evaluation of Histopathological Fingings, Paired Resection Biopsy Specimens, and the Effect of Neoadjuvant Therapy: A Single Center Study*. Turkish Journal of Gastroenterology, 36(6), 357–370. https://doi.org/10.5152/tjg.2025.24488
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