Published In
Turkish Journal of Gastroenterology
Volume 33 · Issue 10
Pages: 862-873
History
Published Online: October 15, 2022
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright © 2022 Yusuf Önlen, Tayibe Bal, Mehmet Çabalak, Nefise Çuvalcı Öztoprak, Nagehan Didem Sarı, Behice Kurtaran, Ebubekir Şenateş, Alper Gündüz, Esra Zerdali, Hasan Karsen, Ayşe Batırel, Rıdvan Karaali, Rahmet Güner, Tansu Yamazhan, Şükran Köse, Nurettin Erben, Nevin İnce, İftihar Köksal, Figen Sarıgül Yıldırım, Gülşen Yörük, Süheyla Kömür, Sibel Kaya, Şaban Esen, Özgür Günal, İlknur Esen Yıldız, Dilara İnan, Şener Barut, Mustafa Namıduru, Selma Tosun, Kamuran Türker, Alper Şener, Kenan Hızel, Nurcan Baykam, Fazilet Duygu, Esragül Akıncı, Güray Can, Ülkü User, Hanefi Cem Gül, Ayhan Akbulut, Güven Çelebi, Mahmut Sünnetçioğlu, Oğuz Karabay, Hayat Kumbasar Karaosmanoğlu, Fatma Sırmatel, Fehmi Tabak
Yusuf Önlen
Turkish Association for the Study of the Liver, Istanbul, Turkey; Viral Hepatitis Society, Ankara, Turkey
Tayibe Bal
Mustafa Kemal University Faculty of Medicine, Antakya, Turkey
Mehmet Çabalak
Mustafa Kemal University Faculty of Medicine Infectious Diseases Department, Hatay, Turkey
Nefise Çuvalcı Öztoprak
Antalya Training and Research Hospital, Infectious Diseases, Antalya, Turkey
Nagehan Didem Sarı
Departments of Clinical Microbiology and Infectious Diseases, İstanbul Education and Research Hospital, İstanbul
Behice Kurtaran
Department of Infectious Diseases, Çukurova University Faculty of Medicine, Adana, Turkey
Ebubekir Şenateş
Department of Gastroenterology, İstanbul Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey
Alper Gündüz
Department of Infectious Diseases, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey
Esra Zerdali
Haseki Training and Research Hospital Department of Infectious Diseases, İstanbul, Turkey
Hasan Karsen
Harran University Faculty of Medicine Infectious Diseases Department, Şanlıurfa, Turkey
Ayşe Batırel
Department of Infectious Diseases and Clinical Microbiology, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey
Rıdvan Karaali
Department of Infectious Diseases and Clinical Microbiology, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey
Rahmet Güner
Department of Infectious diseases, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey
Tansu Yamazhan
Turkish Association for the Study of the Liver, İstanbul, Turkey; Viral Hepatitis Society, Ankara, Turkey
Şükran Köse
Clinics of Infectious Diseases and Clinical Microbiology, Ministry of Health İzmir Tepecik Education and Research Hospital, İzmir
Nurettin Erben
Department of Infectious Diseases and Clinical Microbiology, Eskişehir Osman Gazi University, Eskişehir, Turkey
Nevin İnce
Düzce Üniversity, Düzce, Turkey
İftihar Köksal
KTÜ Tıp Fakültesi İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Trabzon
Figen Sarıgül Yıldırım
Department of Infectious Diseases, Antalya Training and Research Hospital, Antalya, Turkey
Gülşen Yörük
Department of Infectious Diseases, İstanbul Training and Research Hospital, İstanbul, Turkey
Süheyla Kömür
Department of Infectious Diseases, Çukurova University Faculty of Medicine, Adana, Turkey
Sibel Kaya
Istanbul University Faculty of Medicine Infectious Diseases Department, İstanbul, Turkey
Şaban Esen
Turkish Association for the Study of the Liver, İstanbul, Turkey; Viral Hepatitis Society, Ankara, Turkey
Özgür Günal
Department of Infectious Diseases and Clinical Microbiology, Gaziosmanpaşa Universtiy Faculty of Medicine, Tokat, Turkey
İlknur Esen Yıldız
Department of Infectious Diseases and Clinical Microbiology, Rize University School of Medicine, Rize, Turkey
Dilara İnan
Turkish Association for the Study of the Liver, İstanbul, Turkey; Viral Hepatitis Society, Ankara, Turkey
Şener Barut
Departments of Clinical Bacteriology and Infectious Disease, Gaziosmanpafla University, School of Medicine, Tokat
Mustafa Namıduru
Department of Infectious Diseases and Clinical Microbiology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey
Selma Tosun
Turkish Association for the Study of the Liver, Istanbul, Turkey; Viral Hepatitis Society, Ankara, Turkey
Kamuran Türker
Bağcılar Training and Research Hospital Department of Infectious Diseases, İstanbul, Turkey
Alper Şener
Department of Infectious Diseases and Clinical Microbiology, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Turkey
Kenan Hızel
Gazi University Faculty of Medicine Infectious Diseases Department, Ankara, Turkey
Nurcan Baykam
Ankara Numune Hospital, Enfeksiyon Hospital, Infection Diseases and Clinical Microbiology Department, Ankara
Fazilet Duygu
Department of Infectious Diseases and Clinical Microbiology, Gaziosmanpaşa Universtiy Faculty of Medicine, Tokat, Turkey
Esragül Akıncı
Department of Infectious Diseases, Ankara Numune Training and Research Hospital, Ankara, Turkey
Güray Can
Department of Gastroenterology, Abant İzzet Baysal University School of Medicine, Bolu, Turkey
Ülkü User
Department of Infectious Diseases and Clinical Microbiology, Çukurova University Faculty of Medicine, Adana, Turkey
Hanefi Cem Gül
Department of Infectious Diseases, Gülhane Training and Research Hospital, Ankara, Turkey
Ayhan Akbulut
Turkish Association for the Study of the Liver, İstanbul, Turkey; Viral Hepatitis Society, Ankara, Turkey
Güven Çelebi
Department of Infectious Diseases and Clinical Microbiology, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey
Mahmut Sünnetçioğlu
Department of Infectious Diseases and Clinical Microbiology, Yüzüncü Yıl University Faculty of Medicine, Van, Turkey
Oğuz Karabay
Infectious Diseases Department İzzet Baysal Medical Faculty
Hayat Kumbasar Karaosmanoğlu
Bakırköy Sadi Konuk Training and Research Hospital, Infectious Diseases Department, İstanbul, Turkey
Fatma Sırmatel
Turkish Association for the Study of the Liver, İstanbul, Turkey; Viral Hepatitis Society, Ankara, Turkey
Fehmi Tabak
İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi İç Hastalıkları, Kardiyoloji, Patoloji Anabilim Dalları, İstanbul
Önlen, Y., Bal, T., Çabalak, M., Çuvalcı Öztoprak, N., Sarı, N. D., Kurtaran, B., … Tabak, F. (2022). Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey. Turkish Journal of Gastroenterology, 33(10), 862–873. https://doi.org/10.5152/tjg.2022.21271
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Abstract
Background: The number and proportion of elderly patients living with chronic hepatitis C are expected to increase in the coming years. We aimed to compare the real-world efficacy and safety of direct-acting antiviral treatment in elderly and younger Turkish adults infected with chronic hepatitis C. Methods: In this multicenter prospective study, 2629 eligible chronic hepatitis C patients treated with direct-acting antivirals between April 2017 and December 2019 from 37 Turkish referral centers were divided into 2 age groups: elderly (≥65 years) and younger adults (<65 years) and their safety was compared between 2 groups in evaluable population. Then, by matching the 2 age groups for demographics and pretreatment risk factors for a non-sustained virological response, a total of 1516 patients (758 in each group) and 1244 patients (622 in each group) from the modified evaluable population and per-protocol population were included in the efficacy analysis and the efficacy was compared between age groups. Results: The sustained virological response in the chronic hepatitis C patients was not affected by the age and the presence of cirrhosis both in the modified evaluable population and per-protocol population (P = .879, P = .508 for modified evaluable population and P = .058, P = .788 for per-protocol population, respectively). The results of the per-protocol analysis revealed that male gender, patients who had a prior history of hepatocellular carcinoma, patients infected with non-genotype 1 hepatitis C virus, and patients treated with sofosbuvir+ribavirin had a significantly lower sustained virological response 12 rates (P < .001, P = .047, P = .013, and P = .025, respectively). Conclusion: Direct-acting antivirals can be safely used to treat Turkish elderly chronic hepatitis C patients with similar favorable efficacy and safety as that in younger adults. Cite this article as: Önlen Y, Bal T, Çabalak M, et al. Efficacy and safety of direct-acting antivirals in elderly patients with chronic hepatitis C: A nationwide real-life, observational, multicenter study from Turkey. Turk J Gastroenterol. 2022;33(10):862-873.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 33 · Issue 10
Pages
862-873
History
Published Online
October 15, 2022
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright
Copyright (c) 2022 Yusuf Önlen, Tayibe Bal, Mehmet Çabalak, Nefise Çuvalcı Öztoprak, Nagehan Didem Sarı, Behice Kurtaran, Ebubekir Şenateş, Alper Gündüz, Esra Zerdali, Hasan Karsen, Ayşe Batırel, Rıdvan Karaali, Rahmet Güner, Tansu Yamazhan, Şükran Köse, Nurettin Erben, Nevin İnce, İftihar Köksal, Figen Sarıgül Yıldırım, Gülşen Yörük, Süheyla Kömür, Sibel Kaya, Şaban Esen, Özgür Günal, İlknur Esen Yıldız, Dilara İnan, Şener Barut, Mustafa Namıduru, Selma Tosun, Kamuran Türker, Alper Şener, Kenan Hızel, Nurcan Baykam, Fazilet Duygu, Esragül Akıncı, Güray Can, Ülkü User, Hanefi Cem Gül, Ayhan Akbulut, Güven Çelebi, Mahmut Sünnetçioğlu, Oğuz Karabay, Hayat Kumbasar Karaosmanoğlu, Fatma Sırmatel, Fehmi Tabak
Affiliations
Yusuf Önlen
Turkish Association for the Study of the Liver, Istanbul, Turkey; Viral Hepatitis Society, Ankara, Turkey
Tayibe Bal
Mustafa Kemal University Faculty of Medicine, Antakya, Turkey
Mehmet Çabalak
Mustafa Kemal University Faculty of Medicine Infectious Diseases Department, Hatay, Turkey
Nefise Çuvalcı Öztoprak
Antalya Training and Research Hospital, Infectious Diseases, Antalya, Turkey
Nagehan Didem Sarı
Departments of Clinical Microbiology and Infectious Diseases, İstanbul Education and Research Hospital, İstanbul
Behice Kurtaran
Department of Infectious Diseases, Çukurova University Faculty of Medicine, Adana, Turkey
Ebubekir Şenateş
Department of Gastroenterology, İstanbul Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey
Alper Gündüz
Department of Infectious Diseases, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey
Esra Zerdali
Haseki Training and Research Hospital Department of Infectious Diseases, İstanbul, Turkey
Hasan Karsen
Harran University Faculty of Medicine Infectious Diseases Department, Şanlıurfa, Turkey
Ayşe Batırel
Department of Infectious Diseases and Clinical Microbiology, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey
Rıdvan Karaali
Department of Infectious Diseases and Clinical Microbiology, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey
Rahmet Güner
Department of Infectious diseases, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey
Tansu Yamazhan
Turkish Association for the Study of the Liver, İstanbul, Turkey; Viral Hepatitis Society, Ankara, Turkey
Şükran Köse
Clinics of Infectious Diseases and Clinical Microbiology, Ministry of Health İzmir Tepecik Education and Research Hospital, İzmir
Nurettin Erben
Department of Infectious Diseases and Clinical Microbiology, Eskişehir Osman Gazi University, Eskişehir, Turkey
Nevin İnce
Düzce Üniversity, Düzce, Turkey
İftihar Köksal
KTÜ Tıp Fakültesi İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Trabzon
Figen Sarıgül Yıldırım
Department of Infectious Diseases, Antalya Training and Research Hospital, Antalya, Turkey
Gülşen Yörük
Department of Infectious Diseases, İstanbul Training and Research Hospital, İstanbul, Turkey
Süheyla Kömür
Department of Infectious Diseases, Çukurova University Faculty of Medicine, Adana, Turkey
Sibel Kaya
Istanbul University Faculty of Medicine Infectious Diseases Department, İstanbul, Turkey
Şaban Esen
Turkish Association for the Study of the Liver, İstanbul, Turkey; Viral Hepatitis Society, Ankara, Turkey
Özgür Günal
Department of Infectious Diseases and Clinical Microbiology, Gaziosmanpaşa Universtiy Faculty of Medicine, Tokat, Turkey
İlknur Esen Yıldız
Department of Infectious Diseases and Clinical Microbiology, Rize University School of Medicine, Rize, Turkey
Dilara İnan
Turkish Association for the Study of the Liver, İstanbul, Turkey; Viral Hepatitis Society, Ankara, Turkey
Şener Barut
Departments of Clinical Bacteriology and Infectious Disease, Gaziosmanpafla University, School of Medicine, Tokat
Mustafa Namıduru
Department of Infectious Diseases and Clinical Microbiology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey
Selma Tosun
Turkish Association for the Study of the Liver, Istanbul, Turkey; Viral Hepatitis Society, Ankara, Turkey
Kamuran Türker
Bağcılar Training and Research Hospital Department of Infectious Diseases, İstanbul, Turkey
Alper Şener
Department of Infectious Diseases and Clinical Microbiology, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Turkey
Kenan Hızel
Gazi University Faculty of Medicine Infectious Diseases Department, Ankara, Turkey
Nurcan Baykam
Ankara Numune Hospital, Enfeksiyon Hospital, Infection Diseases and Clinical Microbiology Department, Ankara
Fazilet Duygu
Department of Infectious Diseases and Clinical Microbiology, Gaziosmanpaşa Universtiy Faculty of Medicine, Tokat, Turkey
Esragül Akıncı
Department of Infectious Diseases, Ankara Numune Training and Research Hospital, Ankara, Turkey
Güray Can
Department of Gastroenterology, Abant İzzet Baysal University School of Medicine, Bolu, Turkey
Ülkü User
Department of Infectious Diseases and Clinical Microbiology, Çukurova University Faculty of Medicine, Adana, Turkey
Hanefi Cem Gül
Department of Infectious Diseases, Gülhane Training and Research Hospital, Ankara, Turkey
Ayhan Akbulut
Turkish Association for the Study of the Liver, İstanbul, Turkey; Viral Hepatitis Society, Ankara, Turkey
Güven Çelebi
Department of Infectious Diseases and Clinical Microbiology, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey
Mahmut Sünnetçioğlu
Department of Infectious Diseases and Clinical Microbiology, Yüzüncü Yıl University Faculty of Medicine, Van, Turkey
Oğuz Karabay
Infectious Diseases Department İzzet Baysal Medical Faculty
Hayat Kumbasar Karaosmanoğlu
Bakırköy Sadi Konuk Training and Research Hospital, Infectious Diseases Department, İstanbul, Turkey
Fatma Sırmatel
Turkish Association for the Study of the Liver, İstanbul, Turkey; Viral Hepatitis Society, Ankara, Turkey
Fehmi Tabak
İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi İç Hastalıkları, Kardiyoloji, Patoloji Anabilim Dalları, İstanbul
Cite this Article
Önlen, Y., Bal, T., Çabalak, M., Çuvalcı Öztoprak, N., Sarı, N. D., Kurtaran, B., … Tabak, F. (2022). Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey. Turkish Journal of Gastroenterology, 33(10), 862–873. https://doi.org/10.5152/tjg.2022.21271
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