Original Article

Is Having Inflammatory Bowel Disease a Risk Factor for Severe Acute Respiratory Syndrome Coronavirus 2?

Volume 33 · Issue 3 Publish Date: March 15, 2022
Bilger Çavuş Filiz Akyüz Aslı Örmeci Çifçibaşı İlker Özgür Cansu Erel Aysun Yakut Ziya İmanov İbrahim Volkan Şenkal Alpay Medetalibeyoğlu Murat Köse Metin Keskin Kadir Demir Fatih Beşışık Sabahattin Kaymakoğlu
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Published In

Turkish Journal of Gastroenterology

Volume 33 · Issue 3

Pages: 196-204

History

Published Online: March 15, 2022

Copyright © 2022 Bilger Çavuş, Filiz Akyüz, Aslı Örmeci Çifçibaşı, İlker Özgür, Cansu Erel, Aysun Yakut, Ziya İmanov, İbrahim Volkan Şenkal, Alpay Medetalibeyoğlu, Murat Köse, Metin Keskin, Kadir Demir, Fatih Beşışık, Sabahattin Kaymakoğlu

Bilger Çavuş
Department of Internal Medicine, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Filiz Akyüz
Covering the Cover Editor
Aslı Örmeci Çifçibaşı
Division of Gastroenterology, Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
İlker Özgür
Department of General Surgery, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
Cansu Erel
Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
Aysun Yakut
Division of Gastroenterology, Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
Ziya İmanov
Division of Gastroenterology, Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
İbrahim Volkan Şenkal
Division of Gastroenterology, Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
Alpay Medetalibeyoğlu
Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
Murat Köse
Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
Metin Keskin
Department of General Surgery, İstanbul University, İstanbul School of Medicine, İstanbul, Turkey
Kadir Demir
İstanbul Üniversitesi, İstanbul Tıp Fakültesi Gastroenteropatoloji Bilim Dalı ve Patoloji anabilim Dalı, İstanbul
Fatih Beşışık
Departments of Gastroenterohepatology, İstanbul University İstanbul Medical Faculty, İstanbul
Sabahattin Kaymakoğlu
Department of Gastroenterology, İstanbul University, İstanbul School of Medicine, İstanbul
Çavuş, B., Akyüz, F., Örmeci Çifçibaşı, A., Özgür, İlker, Erel, C., Yakut, A., … Kaymakoğlu, S. (2022). Is Having Inflammatory Bowel Disease a Risk Factor for Severe Acute Respiratory Syndrome Coronavirus 2?. Turkish Journal of Gastroenterology, 33(3), 196–204. https://doi.org/10.5152/tjg.2022.211113
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Abstract

Background: The severe acute respiratory syndrome coronavirus 2 virus was found to have effects not only in the lungs but also in many different organs. We aimed to evaluate the management of our patients with inflammatory bowel disease in this pandemic, the incidence of coronavirus disease 2019 in terms of clinical, medical treatment, and features of inflammatory bowel disease, and to investigate the effects of the severe acute respiratory syndrome coronavirus 2 on this particular group of patients. Methods: During the coronavirus disease 2019 pandemic, 207 patients who had inflammatory bowel disease for at least 6 months were questioned for coronavirus disease 2019 at their outpatient clinic admissions, and their medical records were evaluated prospectively. Results: Of the 207 patients, 146 had Crohn’s disease. The mean disease duration was determined as 118.15 ± 72.85 months. Of the patients, 127 (61.4%) were using mesalazine, 110 (53.1%) azathioprine, and 148 (71.5%) biological agents. It was found that 66 (31.9%) patients changed their medications during the coronavirus disease 2019 pandemic. As a medication change, anti-Tumor Necrosis Factor (TNF) dose was observed to be omitted most frequently at a rate of 80%. Diarrhea was present in 20.8%, abdominal pain in 20.3%, nausea in 10.6%, anorexia in 13.5%, and weight loss in 15.9% of the patients. Twelve (5.79%) patients were diagnosed with coronavirus disease 2019. Lung involvement was present in 11 (91.7%) of the patients diagnosed with coronavirus disease 2019. Of the patients diagnosed and not diagnosed with coronavirus disease 2019, 75% vs. 71.6% were using biological agents (P = .80), respectively. Half of the patients diagnosed with coronavirus disease 2019 were active in terms of inflammatory bowel disease at the time of diagnosis, and 2 of these patients were severely active. Conclusion: The incidence of coronavirus disease 2019 infection in patients with inflammatory bowel disease was not different from the general population during the severe acute respiratory syndrome coronavirus 2 pandemic. Coronavirus disease 2019 infection does not progress with poor prognosis in patients with inflammatory bowel disease who receive immunosuppressive therapy including biological agents

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 33 · Issue 3
Pages 196-204
DOI 10.5152/tjg.2022.211113
History
Published Online March 15, 2022
Copyright
Copyright (c) 2022 Bilger Çavuş, Filiz Akyüz, Aslı Örmeci Çifçibaşı, İlker Özgür, Cansu Erel, Aysun Yakut, Ziya İmanov, İbrahim Volkan Şenkal, Alpay Medetalibeyoğlu, Murat Köse, Metin Keskin, Kadir Demir, Fatih Beşışık, Sabahattin Kaymakoğlu
Affiliations
Bilger Çavuş
Department of Internal Medicine, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Filiz Akyüz
Covering the Cover Editor
Aslı Örmeci Çifçibaşı
Division of Gastroenterology, Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
İlker Özgür
Department of General Surgery, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
Cansu Erel
Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
Aysun Yakut
Division of Gastroenterology, Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
Ziya İmanov
Division of Gastroenterology, Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
İbrahim Volkan Şenkal
Division of Gastroenterology, Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
Alpay Medetalibeyoğlu
Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
Murat Köse
Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
Metin Keskin
Department of General Surgery, İstanbul University, İstanbul School of Medicine, İstanbul, Turkey
Kadir Demir
İstanbul Üniversitesi, İstanbul Tıp Fakültesi Gastroenteropatoloji Bilim Dalı ve Patoloji anabilim Dalı, İstanbul
Fatih Beşışık
Departments of Gastroenterohepatology, İstanbul University İstanbul Medical Faculty, İstanbul
Sabahattin Kaymakoğlu
Department of Gastroenterology, İstanbul University, İstanbul School of Medicine, İstanbul
Cite this Article
Çavuş, B., Akyüz, F., Örmeci Çifçibaşı, A., Özgür, İlker, Erel, C., Yakut, A., … Kaymakoğlu, S. (2022). Is Having Inflammatory Bowel Disease a Risk Factor for Severe Acute Respiratory Syndrome Coronavirus 2?. Turkish Journal of Gastroenterology, 33(3), 196–204. https://doi.org/10.5152/tjg.2022.211113
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