Published In
Turkish Journal of Gastroenterology
Volume 36 · Issue 4
Pages: 219-228
History
Published Online: January 6, 2025
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright © 2025 Merve Guzel Dirim, Asli Cifcibasi Ormeci, Bilger Cavus, Arzu Poyanli, Kursat Rahmi Serin, Filiz Akyuz, Kadir Demir, Selman Fatih Besisik, Sabahattin Kaymakoglu
Merve Guzel Dirim
Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Asli Cifcibasi Ormeci
Division of Gastr oente rohep atolo gy, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Bilger Cavus
Division of Gastr oente rohep atolo gy, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Arzu Poyanli
Department of Radiology, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Kursat Rahmi Serin
Department of General Surgery, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiy
Filiz Akyuz
Division of Gastr oente rohep atolo gy, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Kadir Demir
Division of Gastr oente rohep atolo gy, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Selman Fatih Besisik
Division of Gastr oente rohep atolo gy, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Sabahattin Kaymakoglu
Division of Gastr oente rohep atolo gy, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Guzel Dirim, M., Cifcibasi Ormeci, A., Cavus, B., Poyanli, A., Serin, K. R., Akyuz, F., … Kaymakoglu, S. (2025). Inflammation and Immune-Based Scores Predict Prognosis for Patients with Hepatocellular Carcinoma: A Pilot Single-Center Study. Turkish Journal of Gastroenterology, 36(4), 219–228. https://doi.org/10.5152/tjg.2025.24407
Abstract
Background/Aims: Hepatocellular carcinoma (HCC) ranks as a major contributor to cancer-related deaths. Systemic inflammation plays a pivotal role in HCC development and progression. Thus, we aimed to determine the impact of inflammation- and immune-based scores in predicting the prognosis of HCC.
Materials and Methods: In this retrospective study, patients with HCC were enrolled between 2010 and 2020. The purpose of this ret rospective study was to evaluate the impact of various biomarkers, including baseline alpha fetoprotein (AFP) levels, C-reactive protein (CRP) –albu min–l ympho cyte (CALLY) index, neutrophil-to-CRP (N/CRP) ratio, systemic immune-inflammation index (SII), albumin–bili rubin (ALBI) score, neutr ophil -to-l ympho cyte ratio (NLR), and aspartate aminotransferase (AST)-to-alanine aminotransferase (ALT) (AST/ALT) ratio (AAR), on survival, invasion of vascular tracts, metastasis, and treatment responses.
Results: A total of 199 patients with complete (n = 44) and non-complete (n = 145) treatment response groups were enrolled in the study. All scores for the non-complete response group were statistically significant (P < .05). The areas under the curves for predicting a non-complete response group were 0.651, 0.649, 0.636, 0.625, 0.613, 0.609, and 0.600 for AFP, CALLY index, AAR, SII, N/CRP ratio, ALBI score, and NLR, respectively. These results are consistent with the assessment of mortality and HCC progression.
Conclusion: Our results indicate that these biomarkers could serve as powerful prognostic tools for HCC.
Cite this article as: Guzel Dirim M, Cifcibasi Ormeci A, Cavus B, et al. Inflammation and immune-based scores predict prognosis for patients with hepatocellular carcinoma: A pilot single-center study. Turk J Gastroenterol. 2025;36(4):219-228.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 36 · Issue 4
Pages
219-228
History
Published Online
January 6, 2025
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright
Copyright (c) 2025 Merve Guzel Dirim, Asli Cifcibasi Ormeci, Bilger Cavus, Arzu Poyanli, Kursat Rahmi Serin, Filiz Akyuz, Kadir Demir, Selman Fatih Besisik, Sabahattin Kaymakoglu
Affiliations
Merve Guzel Dirim
Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Asli Cifcibasi Ormeci
Division of Gastr oente rohep atolo gy, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Bilger Cavus
Division of Gastr oente rohep atolo gy, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Arzu Poyanli
Department of Radiology, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Kursat Rahmi Serin
Department of General Surgery, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiy
Filiz Akyuz
Division of Gastr oente rohep atolo gy, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Kadir Demir
Division of Gastr oente rohep atolo gy, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Selman Fatih Besisik
Division of Gastr oente rohep atolo gy, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Sabahattin Kaymakoglu
Division of Gastr oente rohep atolo gy, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Cite this Article
Guzel Dirim, M., Cifcibasi Ormeci, A., Cavus, B., Poyanli, A., Serin, K. R., Akyuz, F., … Kaymakoglu, S. (2025). Inflammation and Immune-Based Scores Predict Prognosis for Patients with Hepatocellular Carcinoma: A Pilot Single-Center Study. Turkish Journal of Gastroenterology, 36(4), 219–228. https://doi.org/10.5152/tjg.2025.24407
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