Liver - Original Article

Evaluation of Magnetic Resonance Elastography and Transient Elastography for Liver Fibrosis and Steatosis Assessments in the Liver Transplant Setting

Volume 33 · Issue 2 Publish Date: February 15, 2022
Zeynep Melekoglu Ellik Ilkay S. Idilman Aysun Kartal Yasemin Balaban Atilla H. Elhan Musturay Karcaaltincaba Hasan Ozkan Ramazan Idilman
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Turkish Journal of Gastroenterology

Volume 33 · Issue 2

Pages: 153-160

History

Published Online: February 15, 2022

Copyright © 2022 Zeynep Melekoglu Ellik, Ilkay S. Idilman, Aysun Kartal, Yasemin Balaban, Atilla H. Elhan, Musturay Karcaaltincaba, Hasan Ozkan, Ramazan Idilman

Zeynep Melekoglu Ellik
Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey
Ilkay S. Idilman
Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey
Aysun Kartal
Ankara University School of Medicine, Department of Gastroenterology, Ankara, Turkey
Yasemin Balaban
Department of pathology, Hacettepe University Medical School, Ankara, Turkey
Atilla H. Elhan
Department of Biostatistics, Ankara University School of Medicine, Ankara, Turkey
Musturay Karcaaltincaba
Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey
Hasan Ozkan
Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey
Ramazan Idilman
Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey
Melekoglu Ellik, Z., Idilman, I. S., Kartal, A., Balaban, Y., Elhan, A. H., Karcaaltincaba, M., … Idilman, R. (2022). Evaluation of Magnetic Resonance Elastography and Transient Elastography for Liver Fibrosis and Steatosis Assessments in the Liver Transplant Setting. Turkish Journal of Gastroenterology, 33(2), 153–160. https://doi.org/10.5152/tjg.2022.21705
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Abstract

Background: Liver graft fibrosis affects long-term graft and patient survival in liver transplant recipients. Transient elastography and magnetic resonance elastography are widely used for the assessment of liver fibrosis in routine clinical practice, but are limited in liver transplant settings. The aims of the present study were to evaluate the accuracy of magnetic resonance elastography and transient elastograph in the assessment of liver fibrosis in liver transplant recipients, and to determine the recurrence rates of post-transplant hepatic steatosis and liver fibrosis. Methods: A total of 126 consecutive liver transplant recipients were included. Magnetic resonance elastography and transient elastography were performed for to measure liver stiffness. Results: The most common cause of liver transplantation was hepatitis B virus-induced cirrhosis (50%). The mean liver stiffness value with transient elastography was 6.1 ± 3.0 kPa, and the mean magnetic resonance elastography value was 2.7 ± 1.0 kPa. A significant positive correlation was found between magnetic resonance elastography and transient elastography in terms of liver stiffness measurement (r = 0.61, P < .001). Obesity and the underlying etiology of liver diseases did not have any significant negative effect on magnetic resonance elastography and transient elastography measurements. During the follow-up, the post-transplant recurrence rates of hepatic steatosis and hepatic fibrosis were 26% and 37%, respectively. The recurrence rates of post-transplant hepatic steatosis and liver fibrosis were slightly higher in recipients with non-alcoholic fatty liver disease-related cirrhosis than those with viral hepatitisrelated etiologies (44% vs 27%, P = .43; 44% vs 30%, P = .45, respectively). Conclusion: Magnetic resonance elastography and transient elastography are accurate in assessing liver fibrosis in the liver transplant setting. Obesity and the underlying etiology of primary liver disease do not influence the measurements.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 33 · Issue 2
Pages 153-160
DOI 10.5152/tjg.2022.21705
History
Published Online February 15, 2022
Copyright
Copyright (c) 2022 Zeynep Melekoglu Ellik, Ilkay S. Idilman, Aysun Kartal, Yasemin Balaban, Atilla H. Elhan, Musturay Karcaaltincaba, Hasan Ozkan, Ramazan Idilman
Affiliations
Zeynep Melekoglu Ellik
Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey
Ilkay S. Idilman
Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey
Aysun Kartal
Ankara University School of Medicine, Department of Gastroenterology, Ankara, Turkey
Yasemin Balaban
Department of pathology, Hacettepe University Medical School, Ankara, Turkey
Atilla H. Elhan
Department of Biostatistics, Ankara University School of Medicine, Ankara, Turkey
Musturay Karcaaltincaba
Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey
Hasan Ozkan
Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey
Ramazan Idilman
Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey
Cite this Article
Melekoglu Ellik, Z., Idilman, I. S., Kartal, A., Balaban, Y., Elhan, A. H., Karcaaltincaba, M., … Idilman, R. (2022). Evaluation of Magnetic Resonance Elastography and Transient Elastography for Liver Fibrosis and Steatosis Assessments in the Liver Transplant Setting. Turkish Journal of Gastroenterology, 33(2), 153–160. https://doi.org/10.5152/tjg.2022.21705
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