Published In
Turkish Journal of Gastroenterology
Volume 32 · Issue 12
Pages: 1019-1028
History
Published Online: December 15, 2021
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright © 2021 Ulus Salih Akarca, Belkis Unsal, Orhan Sezgin, Kendal Yalcin, Meral Akdogan, Can Gonen, Feyza Gunduz, Seren Ozenirler, Abdullah Sonsuz, Dinc Dincer, Salim Basol Tekin, Idris Yucel, Hakan Akbulut, Canan Alkım, Ozgur Ozyilkan, Arzu Baygul, Zeynep Merve Cevik, Ramazan Idilman, on behalf of 3K Registry Study Group
Ulus Salih Akarca
Ege Üniversitesi Tıp Fakültesi Gastroenteroloji ve Mikrobiyoloji Anabilim Dalları, İzmir
Belkis Unsal
Clinic of Gastroenterology, Izmir Ataturk Training and Research Hospital, Izmir, Turkey
Orhan Sezgin
Department of Gastroenterology, Mersin University Faculty of Medicine, Mersin, Turkey
Kendal Yalcin
Department of Gastroenterology, Dicle University Faculty of Medicine, Diyarbakir, Turkey
Meral Akdogan
Department of Gastroenterology, Turkiye Yuksek Ihtisas Research and Training Hospital, Ankara, Turkey
Can Gonen
Clinic of Gastroenterology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey
Feyza Gunduz
Marmara University, School of Medicine, Department of Gastroenterology, İstanbul, Turkey
Seren Ozenirler
Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey
Abdullah Sonsuz
Cerrahpaşa Tıp Fakültesi İç Hastalıkları Anabilim Dalları, İstanbul
Dinc Dincer
Department of Gastroenterology, Akdeniz University Faculty of Medicine, Antalya, Turkey
Salim Basol Tekin
Department of Oncology, Ataturk University Faculty of Medicine, Erzurum, Turkey
Idris Yucel
Department of Oncology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey
Hakan Akbulut
Tıbbi Onkoloji
Canan Alkım
T.Y.İ.H. Gastroenteroloji Kliniği İ.B.H. Ünitesi, Ankara
Ozgur Ozyilkan
Department of Oncology, Adana Baskent University Faculty of Medicine, Adana, Turkey
Arzu Baygul
Department of Biostatistics, Koc University School of Medicine, Istanbul, Turkey
Zeynep Merve Cevik
Medical Management, Bayer Türk, Istanbul, Turkey
Ramazan Idilman
Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey
Akarca, U. S., Unsal, B., Sezgin, O., Yalcin, K., Akdogan, M., Gonen, C., … Idilman, R. (2021). Characteristics of Newly Diagnosed Hepatocellular Carcinoma Patients Across Turkey: Prospective Multicenter Observational 3K Registry Study. Turkish Journal of Gastroenterology, 32(12), 1019–1028. https://doi.org/10.5152/tjg.2021.201171
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Abstract
Aims: To evaluate patient profile for epidemiological and clinicopathological characteristics and potential risk/prognostic factors in
newly diagnosed hepatocellular carcinoma (HCC) patients across Turkey.
Methods: A total of 547 patients (mean (SD) age 62.6 (10.3) years, 81.9% were males) were included in this registry study. Data on
patient characteristics, etiologies of HCC, laboratory values, and tumor characteristics and stages were recorded at study enrollment.
Results: HBV infection (68.2%) was the leading etiology, followed by HCV infection (17.2%), HDV infection (5.5%), alcohol (6.4%), and
NAFLD (3.5%), as the major etiologies. Considering that 51.6% of the patients had >5 cm HCC, 44% were Child–Pugh B/C and 57%
were BCLC B-D, it appears that a significant group of HCC patients were diagnosed at advanced stages. Of 540 patients, 271 (50.2%)
were referred or applied with the diagnosis of HCC. Patients with HCC at presentation had larger tumor size (median (min-max) 6.6
(0-30) vs. 4.8 (0-90) cm, P < .001) and more advanced BCLC stage (Stage C-D in 40.8% vs. 26.4%, respectively, P = .005), compared to
patients who were diagnosed during follow-up.
Conclusions: Our findings revealed that HBV infection was the leading etiology and a moderate-to-advanced disease was evident in
more than half of patients at the time of diagnosis. HCC patients diagnosed at follow-up had smaller tumor size and earlier BCLC stage
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 32 · Issue 12
Pages
1019-1028
History
Published Online
December 15, 2021
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright
Copyright (c) 2021 Ulus Salih Akarca, Belkis Unsal, Orhan Sezgin, Kendal Yalcin, Meral Akdogan, Can Gonen, Feyza Gunduz, Seren Ozenirler, Abdullah Sonsuz, Dinc Dincer, Salim Basol Tekin, Idris Yucel, Hakan Akbulut, Canan Alkım, Ozgur Ozyilkan, Arzu Baygul, Zeynep Merve Cevik, Ramazan Idilman, on behalf of 3K Registry Study Group
Affiliations
Ulus Salih Akarca
Ege Üniversitesi Tıp Fakültesi Gastroenteroloji ve Mikrobiyoloji Anabilim Dalları, İzmir
Belkis Unsal
Clinic of Gastroenterology, Izmir Ataturk Training and Research Hospital, Izmir, Turkey
Orhan Sezgin
Department of Gastroenterology, Mersin University Faculty of Medicine, Mersin, Turkey
Kendal Yalcin
Department of Gastroenterology, Dicle University Faculty of Medicine, Diyarbakir, Turkey
Meral Akdogan
Department of Gastroenterology, Turkiye Yuksek Ihtisas Research and Training Hospital, Ankara, Turkey
Can Gonen
Clinic of Gastroenterology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey
Feyza Gunduz
Marmara University, School of Medicine, Department of Gastroenterology, İstanbul, Turkey
Seren Ozenirler
Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey
Abdullah Sonsuz
Cerrahpaşa Tıp Fakültesi İç Hastalıkları Anabilim Dalları, İstanbul
Dinc Dincer
Department of Gastroenterology, Akdeniz University Faculty of Medicine, Antalya, Turkey
Salim Basol Tekin
Department of Oncology, Ataturk University Faculty of Medicine, Erzurum, Turkey
Idris Yucel
Department of Oncology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey
Hakan Akbulut
Tıbbi Onkoloji
Canan Alkım
T.Y.İ.H. Gastroenteroloji Kliniği İ.B.H. Ünitesi, Ankara
Ozgur Ozyilkan
Department of Oncology, Adana Baskent University Faculty of Medicine, Adana, Turkey
Arzu Baygul
Department of Biostatistics, Koc University School of Medicine, Istanbul, Turkey
Zeynep Merve Cevik
Medical Management, Bayer Türk, Istanbul, Turkey
Ramazan Idilman
Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey
Cite this Article
Akarca, U. S., Unsal, B., Sezgin, O., Yalcin, K., Akdogan, M., Gonen, C., … Idilman, R. (2021). Characteristics of Newly Diagnosed Hepatocellular Carcinoma Patients Across Turkey: Prospective Multicenter Observational 3K Registry Study. Turkish Journal of Gastroenterology, 32(12), 1019–1028. https://doi.org/10.5152/tjg.2021.201171
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