Pancreatobiliary - Original Article

Dynamic thiol/disulphide homeostasis in acute pancreatitis

Volume 29 · Issue 3 Publish Date: May 15, 2018
Hüseyin Köseoğlu Murat Alışık Murat Başaran Öykü Tayfur Yürekli Tevfik Solakoğlu Mustafa Tahtacı
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Turkish Journal of Gastroenterology

Volume 29 · Issue 3

Pages: 348-353

History

Published Online: May 15, 2018

Copyright © 2018 Hüseyin Köseoğlu, Murat Alışık, Murat Başaran, Öykü Tayfur Yürekli, Tevfik Solakoğlu, Mustafa Tahtacı

Hüseyin Köseoğlu
Department of Gastroenterology, Atatürk Training and Research Hospital, Ankara, Turkey
Murat Alışık
Department of Clinical Biochemistry, Ankara Atatürk Training and Research Hospital, Ankara, Turkey
Murat Başaran
Department of Gastroenterology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
Öykü Tayfur Yürekli
Department of Gastroenterology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
Tevfik Solakoğlu
Department of Gastroenterology, Çorlu State Hospital, Tekirdağ, Turkey
Mustafa Tahtacı
Department of Gastroenterology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
Köseoğlu, H., Alışık, M., Başaran, M., Tayfur Yürekli, Öykü, Solakoğlu, T., & Tahtacı, M. (2018). Dynamic thiol/disulphide homeostasis in acute pancreatitis. Turkish Journal of Gastroenterology, 29(3), 348–353. https://doi.org/10.5152/tjg.2018.17499
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Abstract

Abstract Background/Aims: The dynamic thiol/disulfide homeostasis plays pivotal roles in many physiological mechanisms in an organism. We aimed to investigate whether dynamic thiol/disulfide homeostasis changes among patients with acute pancreatitis. Materials and Methods: This prospective trial contained 45 patients with acute pancreatitis and 45 sex-and age-matched healthy volunteers as control group. Thiol/disulfide homeostasis parameters were measured by a novel and automated assay, and detected results were compared between the two groups. Results: Disulfide/total thiol percent ratio and disulfide/native thiol percent ratios were significantly higher in acute pancreatitis group; besides the native thiol, total thiol levels and native thiol/total thiol percent ratios were significantly lower (for all p Conclusion: The thiol/disulfide homeostasis is impaired in acute pancreatitis with a shift toward the oxidative status, and this deficiency might be a pathogenic factor in acute pancreatitis. The correction of this thiol/disulfide imbalance may be a new target in the management of acute pancreatitis. Cite this article as: Köseoğlu H, Alışık M, Başaran M, et al. Dynamic thiol/disulphide homeostasis in acute pancreatitis. Turk J Gastroenterol 2018; 29: 348-53.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 29 · Issue 3
Pages 348-353
DOI 10.5152/tjg.2018.17499
History
Published Online May 15, 2018
Copyright
Copyright (c) 2018 Hüseyin Köseoğlu, Murat Alışık, Murat Başaran, Öykü Tayfur Yürekli, Tevfik Solakoğlu, Mustafa Tahtacı
Affiliations
Hüseyin Köseoğlu
Department of Gastroenterology, Atatürk Training and Research Hospital, Ankara, Turkey
Murat Alışık
Department of Clinical Biochemistry, Ankara Atatürk Training and Research Hospital, Ankara, Turkey
Murat Başaran
Department of Gastroenterology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
Öykü Tayfur Yürekli
Department of Gastroenterology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
Tevfik Solakoğlu
Department of Gastroenterology, Çorlu State Hospital, Tekirdağ, Turkey
Mustafa Tahtacı
Department of Gastroenterology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
Cite this Article
Köseoğlu, H., Alışık, M., Başaran, M., Tayfur Yürekli, Öykü, Solakoğlu, T., & Tahtacı, M. (2018). Dynamic thiol/disulphide homeostasis in acute pancreatitis. Turkish Journal of Gastroenterology, 29(3), 348–353. https://doi.org/10.5152/tjg.2018.17499
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