Original Article

The prevalence of IgG4-positive plasma cell infiltrates in inflammatory bowel disease patients without autoimmune pancreatitis

Volume 25 · Issue 5 · October 2014 Publish Date: October 15, 2014
Firdevs Topal 1 Elif Sarıtaş Yüksel 2 Neşe Ekinci 3 Mete Pekdiker 4 Fulya Çakalağaoğlu 5 Emrah Alper 6 Belkıs Ünsal 7
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Turkish Journal of Gastroenterology

Volume 25 · Issue 5 · October 2014

Pages: 558-562

History

Published Online: October 15, 2014

Copyright © 2014 Firdevs Topal, Elif Sarıtaş Yüksel, Neşe Ekinci, Mete Pekdiker, Fulya Çakalağaoğlu, Emrah Alper, Belkıs Ünsal

Firdevs Topal
Department of Gastroenterology, İzmir Atatürk Teaching and Research Hospital, İzmir, Turkey
Elif Sarıtaş Yüksel
Department of Gastroenterology, Atatürk Training and Research Hospital, İzmir, Turkey
Neşe Ekinci
Department of Pathology, Atatürk Training and Research Hospital İzmir
Mete Pekdiker
Department of Gastroenterology, İzmir Atatürk Teaching and Research Hospital, İzmir, Turkey
Fulya Çakalağaoğlu
Department of Pathology, İzmir Ataturk Teaching and Research Hospital, İzmir, Turkey
Emrah Alper
Department of Gastroenterology, Katip Çelebi University, İzmir Atatürk Training and Research Hospital, İzmir, Turkey
Belkıs Ünsal
Department of Gastroenterology, Katip Çelebi University, İzmir Atatürk Training and Research Hospital, İzmir, Turkey
Topal, F., Sarıtaş Yüksel, E., Ekinci, N., Pekdiker, M., Çakalağaoğlu, F., Alper, E., & Ünsal, B. (2014). The prevalence of IgG4-positive plasma cell infiltrates in inflammatory bowel disease patients without autoimmune pancreatitis. Turkish Journal of Gastroenterology, 25(5), 558–562. https://doi.org/10.5152/tjg.2014.5714
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Abstract

Abstract Background/Aims: IgG4-related autoimmune disease can exist in other organs even when there is no evidence of autoimmune pancreatitis. The aim of our study was to determine the prevalence of IgG4-positive plasma cells in the histopathological evaluations of colon biopsy specimens in IBD patients. Materials and Methods: The number of IgG4-positive plasma cells with strong cytoplasmic immunoreactivity was counted in each colon biopsy from inflammatory bowel disease patients who had no evidence of autoimmune pancreatitis. Five high power fields (HPFs) in the highest density plasma cell infiltration area were counted and were then averaged. An average >10 cells/HPF was considered significant for IgG4-related disease. Results: We detected IgG4-positive plasma cell staining in the colon of 21 of 119 patients (17.6%). Of these 21 patients, 5 had elevated serum IgG4 levels (>140 mg/dL). Of the total, 4.2% (5/119) had both IgG4-immunstaining and elevated IgG4 serum levels. The demographic features, disease type and activity, and response to treatment (especially to steroid treatment) were similar between the IgG4-negative and IgG4-positive groups. Conclusion: In our study, 4.2% of patients with the diagnosis of IBD had elevated IgG4 serum levels and significant IGg4 immunostaining. Together, these two parameters indicate the possible diagnosis of an IgG4-related systemic disease.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 25 · Issue 5 · October 2014
Pages 558-562
DOI 10.5152/tjg.2014.5714
History
Published Online October 15, 2014
Copyright
Copyright (c) 2014 Firdevs Topal, Elif Sarıtaş Yüksel, Neşe Ekinci, Mete Pekdiker, Fulya Çakalağaoğlu, Emrah Alper, Belkıs Ünsal
Affiliations
1
Firdevs Topal
Department of Gastroenterology, İzmir Atatürk Teaching and Research Hospital, İzmir, Turkey
2
Elif Sarıtaş Yüksel
Department of Gastroenterology, Atatürk Training and Research Hospital, İzmir, Turkey
3
Neşe Ekinci
Department of Pathology, Atatürk Training and Research Hospital İzmir
4
Mete Pekdiker
Department of Gastroenterology, İzmir Atatürk Teaching and Research Hospital, İzmir, Turkey
5
Fulya Çakalağaoğlu
Department of Pathology, İzmir Ataturk Teaching and Research Hospital, İzmir, Turkey
6
Emrah Alper
Department of Gastroenterology, Katip Çelebi University, İzmir Atatürk Training and Research Hospital, İzmir, Turkey
7
Belkıs Ünsal
Department of Gastroenterology, Katip Çelebi University, İzmir Atatürk Training and Research Hospital, İzmir, Turkey
Cite this Article
Topal, F., Sarıtaş Yüksel, E., Ekinci, N., Pekdiker, M., Çakalağaoğlu, F., Alper, E., & Ünsal, B. (2014). The prevalence of IgG4-positive plasma cell infiltrates in inflammatory bowel disease patients without autoimmune pancreatitis. Turkish Journal of Gastroenterology, 25(5), 558–562. https://doi.org/10.5152/tjg.2014.5714
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