Turkish Journal of Gastroenterology
Original Article

The development of a clinical score for the prediction of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease using routine parameters

1.

Department of Liver Diease, The Affiliated Zhenjiang Third Hospital, Jjiangsu University Faculty of Medicine, Zhenjiang, China

2.

Department of Pathology, The Affiliated Zhenjiang Third Hospital, Jjiangsu University Faculty of Medicine, Zhenjiang, China

3.

Department of Digestive Disease, The Affiliated Zhenjiang Third Hospital, Jjiangsu University Faculty of Medicine, Zhenjiang, China

4.

Department of Sonography, The Affiliated Zhenjiang Third Hospital, Jjiangsu University Faculty of Medicine, Zhenjiang, China

5.

The Affiliated Zhenjiang Third Hospital, Jjiangsu University Faculty of Medicine, Research and Therapy Center for Liver Diease, Zhenjiang, China

Turk J Gastroenterol 2015; 26: 408-416
DOI: 10.5152/tjg.2015.6336
Read: 1939 Downloads: 724 Published: 25 July 2019

Abstract

Background/Aims: To develop a clinical score for the prediction of nonalcoholic steatohepatitis (NASH) using routine parameters in patients with nonalcoholic fatty liver disease who had abnormal liver function tests and/or fatty liver detected by ultrasonography.

 

Materials and Methods: To identify parameters associated with the presence of NASH by evaluating anthropometric characteristics and routine biomarkers of 82 patients with histologically proven NAFLD and to develop a clinical score for predicting NASH according to the area under the curve of receiver operating characteristics (AUC) of parameters.

 

Results: Four parameters [alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), C-reactive protein (CRP), and apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1) ratio] were significantly linked to NASH. The AUROCs of ALT, GGT, CRP, and ApoB/ApoA1 ratio for the prediction of NASH were 0.829, 0.892, 0.708, and 0.712, respectively. The AUROC of the combined clinical score for the prediction of NASH was 0.904 (95% CI, 0.885–1.002) at a cut-off of 3.8 points with a sensitivity of 90.2%, specificity of 87.0%, positive predictive value of 88.3%, and negative predictive value of 91.5%.

 

Conclusion: In the present study, a clinical score was developed for the noninvasive prediction of NASH; the score was based on a combination of routine biochemical parameters and was useful in distinguishing NASH from NAFLD. 

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