Turkish Journal of Gastroenterology

Role of gut microbiota: Obesity and NAFLD


Department of Gastroenterology, Bezmialem Vakif University Medical Faculty, İstanbul, Turkey

Turk J Gastroenterol 2014; 25: 133-140
DOI: 10.5152/tjg.2014.7886
Read: 4179 Downloads: 963 Published: 25 July 2019


Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease in developed countries. Obesity is the most important risk factor for metabolic syndrome and NAFLD. Accumulated evidence has revealed that gut microbial compositional changes may be associated with more energy harvesting from the diet, which promotes increased fatty acid uptake from adipose tissue and shifts lipid metabolism from oxidation to de novo production. Furthermore, changes in intestinal barrier function contribute to metabolic endotoxemia in the form of low-grade microbial inflammation. Persistent inflammation exacerbates NAFLD progression. In this review, we discuss the role of gut microbiota in obesity and NAFLD. 

EISSN 2148-5607