Turkish Journal of Gastroenterology
Original Article

Low-dose ramosetron accelerates gastric emptying in the early phase: A crossover study in healthy volunteers using a continuous real-time 13C breath test (BreathID System)

1.

Department of Medical Education, Yokohama City University School of Medicine, Yokohama, Japan

2.

Gastroenterology Division, Yokohama City University Hospital, Yokohama, Japan

3.

Gastroenterology Division, Yokohama City University Hospital, Yokohama, Japan; Office of Postgraduate Medical Education, Yokohama City University Hospital, Yokohama, Japan

Turk J Gastroenterol 2015; 26: 123-127
DOI: 10.5152/tjg.2015.4768
Read: 1358 Downloads: 420 Published: 25 July 2019

Abstract

Background/Aims: The aim of this study was to determine the correlation between low-dose ramosetron pre-treatment and gastric emptying using a novel, non-invasive technique for measuring gastric emptying, namely, the continuous real-time 13C breath test (BreathID system: Exalenz Bioscience Ltd., Israel).

 

Materials and Methods: Twelve healthy male volunteers participated in this randomized two-way crossover study. The subjects fasted overnight and were randomly assigned to receive the test meal (200 kcal per 200 mL) after an hour pre-treatment with 5 µg ramosetron or the test meal alone. Gastric emptying was monitored for 4 hours after administration of the test meal with the 13C-acetic acid breath test performed continuously using the BreathID system. Using Oridion Research Software (β version), T 1/2, T lag, GEC and the regression-estimated constants (β and κ) were calculated. The differences in the parameters measured at two time-points were analyzed using Wilcoxon’s signed-rank test.

 

Results: There was a significant difference in the calculated parameter β. No significant differences in the calculated parameters T 1/2, T lag, GEC or κ were observed between the test meal with ramosetron group and the test meal alone group.

 

 

Conclusion: This study showed that ramosetron pre-treatment enhances the early gastric emptying of liquid nutrients.

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EISSN 2148-5607