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Gastrointestinal Tract - Original Article

Incidence patterns of colorectal cancers in four countries of the Middle East Cancer Consortium (Cyprus, Jordan, Israel, and İzmir, Turkey) compared with those in the United States Surveillance, Epidemiology, and End Results Program

Sultan Eser 1 , Jenny Chang 2 , Haris Charalambous 3 , Barbara Silverman 4 , Anna Demetriou 3 , Cankut Yakut 5 , Omar Nimri 6 , Pavlos Pavlou 3 , Suriye Özgür 7 , Argyrious Ziogas 2 , Lisa Stevens 8 , Kevin Ward 9 , Hoda Anton-Culver 2
1.

Department of Public Health, Balıkesir University, Balıkesir, Turkey; PI of Regional Hub for Cancer Registration in Northern Africa, Central and, Western Asia, WHO/ IACR GICR, İzmir, Turkey

2.

Department of Epidemiology, University of California Irvine, USA

3.

Cyprus Ministry of Health, Health Monitoring Unit, National Cancer Registry of Cyprus, Nicosia, Cyprus

4.

Israel Ministry of Health, Israel Center for Disease Control, National Cancer Registry of Israel, Israel

5.

Turkish Ministry of Health, İzmir Cancer Registry, İzmir, Turkey

6.

Jordan Ministry of Health, NCDs-Department of Cancer Prevention, National Cancer Registry of Jordan, Jordan

7.

PI of Regional Hub for Cancer Registration in Northern Africa, Central and Western Asia, WHO/ IACR GICR, İzmir, Turkey,

8.

U.S. National Cancer Institute, Center for Global Health, USA

9.

Department of Epidemiology, Georgia Center for Cancer Statistics, Emory University, Georgia

Turk J Gastroenterol 2018; 29: 36-44
DOI: 10.5152/tjg.2018.17263
Keywords : Colorectal cancer, incidence, Cyprus, Turkey, Jordan, Israel
Read: 1978 Downloads: 642 Published: 25 July 2019
Volume 29, Issue 1, January 2018
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Abstract

Background/Aims: There are wide variations in colorectal cancer (CRC) incidence across the world. Historically, the highest incidence rates have been reported historically in more developed countries; however, increasing trends have been seen in developing countries. Here, we present the CRC incidence pattern in Cyprus, Israel, Jordan, and İzmir, Turkey, which are countries of the Middle East Cancer Consortium (MECC).

 

Materials and Methods: We analyzed 2005-2010 CRC data from population-based registries and calculated crude and age standardized rates for CRC, colon and rectum subsites, and annual percent changes (APCs) for trends.

 

Results: The age-adjusted incidence rates (AAIRs) for CRC were the highest in Israeli Jews (IJ) (46.7 for males and 35.5 for females), which exceeded those of the USA Surveillance, Epidemiology, and End Result (SEER) program registries. In both sexes, AAIRs in Cyprus and Israeli Arabs (IA) were close to those in SEER registries. For both sexes, AAIRs in İzmir and Jordan were substantially lower than those in other registries. Statistically significant decreasing trends over time were observed in AAIRs for both sexes in the SEER program (APCs: males, -3.24% and females, -2.54%), whereas the trends varied within the MECC registries. There were decreasing AAIR trends for males in IJ and IA and for females in Cyprus and IJ; APC for females in IJ (-4.29%) was significant. Conversely, increasing trends with the significant APCs were observed in males in İzmir (2.43%) and Jordan (7.57%).

 

Conclusion: MECC countries comprise both high- and low-risk populations for CRCs. However, increasing trends in low-risk populations have been alarming. Thus, the need for implementing tailored primary and secondary prevention programs in the region is essential. 

 

Cite this article as: Eser S, Chang J, Charalambous H, et al. Incidence patterns of colorectal cancers in four countries of the Middle East Cancer Consortium (Cyprus, Jordan, Israel, and İzmir, Turkey) compared with those in the United States Surveillance, Epidemiology, and End Results Program. Turk J Gastroenterol 2018; 29: 35-43.

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