Turkish Journal of Gastroenterology
Invited Review

Etrasimod in Treatment of Ulcerative Colitis: A Comprehensive Review

1.

Department of Gastroenterology, University of Health Sciences, Antalya Training and Research Hospital, Antalya, Türkiye

2.

Department of Gastroenterology, İstanbul Cerrahpaşa University Cerrahpaşa Faculty of Medicine, İstanbul, Türkiye

3.

Gastroenterology and Endoscopy Unit, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University Faculty of Medicine and Surgery, Milan, Italy

Turk J Gastroenterol 2025; 36: 336-342
DOI: 10.5152/tjg.2025.25148
Read: 62 Downloads: 24 Published: 02 June 2025

Ulcerative colitis (UC) is a chronic, inflammatory disease of the colon. The unpredictable, systemic, and debilitating nature of UC puts disease management and patient monitoring at a pivotal point. Despite substantial development in pharmacotherapies for UC in recent years, a significant proportion of patients either fail to respond to treatment or lose their response over the course of the disease. The backbone of disease management in UC is 5-aminosalicylic acid (5-ASA), but patients unresponsive to 5-ASA or with severe disease require advanced therapies including tumor necrosis factor-alpha inhibitors (TNFi), anti-integrins, anti-interleukins and small molecule therapy, Janus kinase (JAK) inhibitors, and S1PR modulators. This review will briefly overview the current state of medical therapeutic options in UC, with further detailing the molecular and clinical aspects of Etrasimod, a sphingosine-1-phosphate receptor (S1PR)
modulator.

Cite this article as: Buldukoglu OC, Erzin Y, Cekin AH, Danese S. Etrasimod in treatment of ulcerative colitis: A comprehensive review. Turk J Gastroenterol. 2025;36(6):336-342.

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EISSN 2148-5607