Turkish Journal of Gastroenterology
Original Article

Diagnostics in cystic echinococcosis: Serology versus ultrasonography

1.

Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany

2.

Section Infection and Clinical Immunology, Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany

3.

Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA

4.

Department of Interventional and Diagnostic Radiology, University Hospital Ulm, Ulm, Germany

5.

WHO Informal Working Group on Echinococcosis, Comprehensive Infectious Diseases Center, University Hospital Ulm, Ulm, Germany

Turk J Gastroenterol 2014; 25: 398-404
DOI: 10.5152/tjg.2014.7112
Read: 160 Downloads: 30 Published: 25 July 2019

Abstract

Background/Aims: Cystic echinococcosis (CE) is the most widespread zoonosis worldwide. The objective of the present study was to compare diagnostic methods in the work-up of suspected cystic echinococcosis of the liver.

 

Materials and Methods: Data from a total of 68 patients were compiled and analyzed.

 

Results: A diagnosis of cystic echinococcosis was made in 36.8% of patients. Broken down according to WHO criteria, patients with at least one echinococcus cyst were determined in 12.0% of cases to exhibit cysts consistent with stage 1 disease (CE1), while in 24.0%, cysts consistent with CE2 and CE3 were identified. CE4 and CE5 cysts were identified in 32.0% and 8.0% of patients, respectively. Solitary cysts were found in 60.0% of patients with cystic echinococcosis, while in patients with at least one cystic lesion, there were most often multiple cysts. The indirect hemagglutination test (IHA) and echinococcus-specific immunoglobulin E (IgE) concentration showed a higher sensitivity (60.9%, 68.4%) than did the enzyme-linked immunosorbent assay (ELISA) for Echinococcus multilocularis (Em2+) and total IgE (11.1%, 38.9%). The respective specificities of all four serological methods lay between 83.9% and 88.9%.

 

Conclusion: Our data show that ultrasound remains the diagnostic method of choice in the work-up of cystic lesions of the liver suspected to be due to Echinococcus granulosus. Serological methods can serve an adjunctive role.

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