Turkish Journal of Gastroenterology
Original Article

Diagnostic and Prognostic Value of Monocyte-to-Lymphocyte Ratio and Red Cell Distribution Width to Lymphocyte Ratio in Primary Biliary Cholangitis

1.

Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi, China

2.

Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China

Turk J Gastroenterol 2023; 34: 170-176
DOI: 10.5152/tjg.2023.21768
Read: 828 Downloads: 291 Published: 01 February 2023

Objective: The aim of this study is to assess levels of monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio in primary biliary cholangitis patients and excavate their clinical significance.

Methods: The levels of monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio in the primary biliary cholangitis, autoimmune hepatitis, and healthy controls were compared, and correlations between monocyte-to-lymphocyte ratio, red cell distribution width-to-lymphocyte ratio, and Mayo score were analyzed. The area under the receiver operating characteristic curve was utilized to analyze the diagnostic value of monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio for primary biliary cholangitis.

Results: Monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio in primary biliary cholangitis were higher than they were in autoimmune hepatitis and healthy controls (each, P < .05). Area under the s of monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio in diagnosis of primary biliary cholangitis were 0.821 and 0.797, respectively (each, P < .001). The combination of monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio increased the diagnostic value of primary biliary cholangitis (area under the receiver operating characteristic curve = 0.868, P < .001). The correlation analysis showed that monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio were positively correlated with Mayo score (r-MLR = 0.459, r-RLR = 0.522, P < .001 for each). Red cell distribution width-to-lymphocyte ratio was independently associated with Mayo score (P = .036) by multiple linear regression. In primary biliary cholangitis patients with Child–Pugh classification, monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio levels in class B and class C were significantly higher than in class A (each, P < .05).

Conclusion: Elevated levels of monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio may prove to be useful markers for estimating the prognosis of primary biliary cholangitis, and the combined detection of monocyte-to-lymphocyte ratio and red cell distribution width-to-lymphocyte ratio has some clinical diagnostic value in patients with primary biliary cholangitis.

Cite this article as: Jiang Y, Wang J, Wu H, Zhou W, Li S, Jin M. Diagnostic and prognostic value of monocyte-to-lymphocyte ratio and red cell distribution width to lymphocyte ratio in primary biliary cholangitis. Turk J Gastroenterol. 2023;34(2):170-176.

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