Turkish Journal of Gastroenterology
Liver - Original Article

Characteristics of Newly Diagnosed Hepatocellular Carcinoma Patients Across Turkey: Prospective Multicenter Observational 3K Registry Study


Department of Gastroenterology, Ege University Faculty of Medicine, Izmir, Turkey


Clinic of Gastroenterology, Izmir Ataturk Training and Research Hospital, Izmir, Turkey


Department of Gastroenterology, Mersin University Faculty of Medicine, Mersin, Turkey


Department of Gastroenterology, Dicle University Faculty of Medicine, Diyarbakir, Turkey


Clinic of Gastroenterology, Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey


Clinic of Gastroenterology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey


Clinic of Gastroenterology, Marmara University Faculty of Medicine Pendik Training and Research Hospital, Istanbul, Turkey


Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey


Department of Gastroenterology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey


Department of Gastroenterology, Akdeniz University Faculty of Medicine, Antalya, Turkey


Department of Oncology, Ataturk University Faculty of Medicine, Erzurum, Turkey


Department of Oncology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey


Department of Oncology, Ankara University Faculty of Medicine, Ankara, Turkey


Clinic of Gastroenterology, Sisli Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey


Department of Oncology, Adana Baskent University Faculty of Medicine, Adana, Turkey


Department of Biostatistics, Koc University School of Medicine, Istanbul, Turkey


Medical Management, Bayer Türk, Istanbul, Turkey


Department of Gastroenterology, Ankara University Faculty of Medicine, Turkey


on behalf of 3K Registry Study Group

Turk J Gastroenterol 2021; 32: 1019-1028
DOI: 10.5152/tjg.2021.201171
Read: 1560 Downloads: 562 Published: 01 December 2021

Aims: To evaluate patient profile for epidemiological and clinicopathological characteristics and potential risk/prognostic factors in newly diagnosed hepatocellular carcinoma (HCC) patients across Turkey.
Methods: A total of 547 patients (mean (SD) age 62.6 (10.3) years, 81.9% were males) were included in this registry study. Data on patient characteristics, etiologies of HCC, laboratory values, and tumor characteristics and stages were recorded at study enrollment.
Results: HBV infection (68.2%) was the leading etiology, followed by HCV infection (17.2%), HDV infection (5.5%), alcohol (6.4%), and NAFLD (3.5%), as the major etiologies. Considering that 51.6% of the patients had >5 cm HCC, 44% were Child–Pugh B/C and 57% were BCLC B-D, it appears that a significant group of HCC patients were diagnosed at advanced stages. Of 540 patients, 271 (50.2%) were referred or applied with the diagnosis of HCC. Patients with HCC at presentation had larger tumor size (median (min-max) 6.6 (0-30) vs. 4.8 (0-90) cm, P < .001) and more advanced BCLC stage (Stage C-D in 40.8% vs. 26.4%, respectively, P = .005), compared to patients who were diagnosed during follow-up.
Conclusions: Our findings revealed that HBV infection was the leading etiology and a moderate-to-advanced disease was evident in more than half of patients at the time of diagnosis. HCC patients diagnosed at follow-up had smaller tumor size and earlier BCLC stage.
Cite this article as: Salih Akarca U, Unsal B, Sezgin O, et al. Characteristics of newly diagnosed hepatocellular carcinoma patients across turkey: prospective multicenter observational 3K registry study. Turk J Gastroenterol. 2021;32(12):1019-1028.

EISSN 2148-5607