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Pancreatic Steatosis: Innocent Bystander or Silent Culprit?

Publish Date: July 20, 2026
Ahmet Sukru Alparslan ORCID Ruhsen Ocal ORCID Osman Cagin Buldukoglu ORCID Serdar Akca ORCID Berna Ozcanoglu ORCID Mert Van ORCID Galip Egemen Atar ORCID Serkan Ocal ORCID Ayhan Hilmi Cekin ORCID
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Turkish Journal of Gastroenterology

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Published Online: July 20, 2026

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Ahmet Sukru Alparslan ORCID
Department of Radiology, Antalya Training and Research Hospital, Antalya, Türkiye
Ruhsen Ocal ORCID
Department of Neurology, Antalya Training and Research Hospital, Antalya, Türkiye
Osman Cagin Buldukoglu ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Serdar Akca ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Berna Ozcanoglu ORCID
Department of Neurology, Antalya Training and Research Hospital, Antalya, Türkiye
Mert Van ORCID
Department of Neurology, Antalya Training and Research Hospital, Antalya, Türkiye
Galip Egemen Atar ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Serkan Ocal ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Ayhan Hilmi Cekin ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Alparslan, A. S., Ocal, R., Buldukoglu, O. C., Akca, S., Ozcanoglu, B., Van, M., … Cekin, A. H. (2026). Pancreatic Steatosis: Innocent Bystander or Silent Culprit?. Turkish Journal of Gastroenterology. https://doi.org/10.5152/tjg.2026.26091
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Abstract

Background/Aims: Pancreatic steatosis (PS) is characterized by fat accumulation within the pancreas and is associated with chronic low-grade inflammation. Migraine, the third most commonly seen disease worldwide, is an established risk factor for white matter lesions (WMLs). Given the shared inflammatory background of these conditions, it was hypothesized that the presence of PS in patients with migraine may contribute to the development of WMLs.

Materials and Methods: This cross-sectional study included patients with migraine who attended the outpatient clinic and had undergone cranial magnetic resonance imaging (MRI) scan for any indication within the last 6 months. Following MRI, patients were referred to the radiology department for transabdominal ultrasonography to assess the presence of PS and hepatosteatosis.

Results: Among the 78 patients with migraine included in the study, 35 (44.9%) had cranial WMLs. PS was significantly more prevalent among patients with WMLs than among those without WMLs (57.4% vs. 16.7%, P < .001). In multivariable logistic regression analysis adjusted for age, body mass index, and low-density lipoprotein/high-density lipoprotein ratio, PS remained independently associated with cranial WMLs (odds ratio (OR) 5.79, 95% CI 1.004-33.41; P = .049). Increasing age was also independently associated with WMLs (OR 1.095 per year, 95% CI 1.018-1.179; P = .015).

Conclusion: This study demonstrated that the presence of PS may contribute to disease burden in patients with migraine. Evaluation of PS in this population may help identify a potentially modifiable metabolic condition and provide additional insight into the management of this common and debilitating disorder.

 

Cite this article as: Alparslan AS, Ocal R, Buldukoglu OC, et al. Pancreatic steatosis: Innocent bystander or silent culprit? Turk J Gastroenterol. Published online July 20, 2026. doi:10.5152/tjg.2026.26091.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
DOI 10.5152/tjg.2026.26091
History
Published Online July 20, 2026
License
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Affiliations
Ahmet Sukru Alparslan ORCID
Department of Radiology, Antalya Training and Research Hospital, Antalya, Türkiye
Ruhsen Ocal ORCID
Department of Neurology, Antalya Training and Research Hospital, Antalya, Türkiye
Osman Cagin Buldukoglu ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Serdar Akca ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Berna Ozcanoglu ORCID
Department of Neurology, Antalya Training and Research Hospital, Antalya, Türkiye
Mert Van ORCID
Department of Neurology, Antalya Training and Research Hospital, Antalya, Türkiye
Galip Egemen Atar ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Serkan Ocal ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Ayhan Hilmi Cekin ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Cite this Article
Alparslan, A. S., Ocal, R., Buldukoglu, O. C., Akca, S., Ozcanoglu, B., Van, M., … Cekin, A. H. (2026). Pancreatic Steatosis: Innocent Bystander or Silent Culprit?. Turkish Journal of Gastroenterology. https://doi.org/10.5152/tjg.2026.26091
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