Published In
Turkish Journal of Gastroenterology
Volume 37 · Issue 8
Pages: 858-868
History
Published Online: June 5, 2026
This work is licensed under a Creative Commons Attribution 4.0 International License.
Alper Uysal
Department of Gastroenterology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Türkiye
Nilay Danış
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Ali Şenkaya
Department of Gastroenterology, Ege University Faculty of Medicine, İzmir, Türkiye
Seymur Aslanov
Gastroenterology Outpatient Clinic, İzmir Medicalpoint Hospital, İzmir, Türkiye
Ilgın Yıldız Şimsir
Department of Endocrinology, Ege University Faculty of Medicine, İzmir, Türkiye
Güliz Armağan
Department of Biochemistry, Ege University Faculty of Pharmacy, İzmir, Türkiye
Rukiye Vardar
Department of Gastroenterology, Ege University Faculty of Medicine, İzmir, Türkiye
Uysal, A., Danış, N., Şenkaya, A., Aslanov, S., Yıldız Şimsir, I., Armağan, G., & Vardar, R. (2026). The Relationship Between Obesity and Intestinal Alkaline Phosphatase: A Clinical and Biochemical Study. Turkish Journal of Gastroenterology, 37(8), 858–868. https://doi.org/10.5152/tjg.2026.26008
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Abstract
Background/Aims: Intestinal alkaline phosphatase (IAP) is a key regulator of gut barrier function, inflammation, and metabolic homeostasis. Human studies evaluating tissue IAP (tIAP) and serum IAP (sIAP) levels in obesity are limited. The current study aimed to investigate the association of sIAP and duodenal IAP levels with obesity and metabolic syndrome (MeS).
Materials and Methods: Fifty-two adults undergoing diagnostic upper endoscopy were prospectively enrolled. sIAP and tIAP levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA), and intestinal IAP expression was assessed by Western blotting. Participants were classified according to body mass index (BMI) and MeS status.
Results: Both sIAP and tIAP levels showed strong inverse correlations with BMI (P < .01) and waist circumference. Obese individuals exhibited significantly lower IAP levels than normal-weight participants (P < .001). tIAP levels were significantly lower in subjects with MeS. Western blot analysis confirmed reduced IAP expression in obese individuals (P = .0139).
Conclusion: Reduced systemic and local IAP levels are associated with obesity and MeS, suggesting that IAP may serve as a potential biomarker for metabolic disease.
Cite this article as: Uysal A, Danış N, Şenkaya A, et al. The relationship between obesity and intestinal alkaline phosphatase: A clinical and biochemical study. Turk J Gastroenterol. 2026;37(8):858-868.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 37 · Issue 8
Pages
858-868
History
Published Online
June 5, 2026
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Affiliations
Alper Uysal
Department of Gastroenterology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Türkiye
Nilay Danış
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Ali Şenkaya
Department of Gastroenterology, Ege University Faculty of Medicine, İzmir, Türkiye
Seymur Aslanov
Gastroenterology Outpatient Clinic, İzmir Medicalpoint Hospital, İzmir, Türkiye
Ilgın Yıldız Şimsir
Department of Endocrinology, Ege University Faculty of Medicine, İzmir, Türkiye
Güliz Armağan
Department of Biochemistry, Ege University Faculty of Pharmacy, İzmir, Türkiye
Rukiye Vardar
Department of Gastroenterology, Ege University Faculty of Medicine, İzmir, Türkiye
Cite this Article
Uysal, A., Danış, N., Şenkaya, A., Aslanov, S., Yıldız Şimsir, I., Armağan, G., & Vardar, R. (2026). The Relationship Between Obesity and Intestinal Alkaline Phosphatase: A Clinical and Biochemical Study. Turkish Journal of Gastroenterology, 37(8), 858–868. https://doi.org/10.5152/tjg.2026.26008
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