Original Article

The Relationship Between Obesity and Intestinal Alkaline Phosphatase: A Clinical and Biochemical Study

Volume 37 · Issue 8 Publish Date: June 5, 2026
Alper Uysal ORCID Nilay Danış ORCID Ali Şenkaya ORCID Seymur Aslanov ORCID Ilgın Yıldız Şimsir ORCID Güliz Armağan ORCID Rukiye Vardar ORCID
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Published In

Turkish Journal of Gastroenterology

Volume 37 · Issue 8

Pages: 858-868

History

Published Online: June 5, 2026

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Alper Uysal ORCID
Department of Gastroenterology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Türkiye
Nilay Danış ORCID
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Ali Şenkaya ORCID
Department of Gastroenterology, Ege University Faculty of Medicine, İzmir, Türkiye
Seymur Aslanov ORCID
Gastroenterology Outpatient Clinic, İzmir Medicalpoint Hospital, İzmir, Türkiye
Ilgın Yıldız Şimsir ORCID
Department of Endocrinology, Ege University Faculty of Medicine, İzmir, Türkiye
Güliz Armağan ORCID
Department of Biochemistry, Ege University Faculty of Pharmacy, İzmir, Türkiye
Rukiye Vardar ORCID
Department of Gastroenterology, Ege University Faculty of Medicine, İzmir, Türkiye
Uysal, A., Danış, N., Şenkaya, A., Aslanov, S., Yıldız Şimsir, I., Armağan, G., & Vardar, R. (2026). The Relationship Between Obesity and Intestinal Alkaline Phosphatase: A Clinical and Biochemical Study. Turkish Journal of Gastroenterology, 37(8), 858–868. https://doi.org/10.5152/tjg.2026.26008
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Abstract

Background/Aims: Intestinal alkaline phosphatase (IAP) is a key regulator of gut barrier function, inflammation, and metabolic homeostasis. Human studies evaluating tissue IAP (tIAP) and serum IAP (sIAP) levels in obesity are limited. The current study aimed to investigate the association of sIAP and duodenal IAP levels with obesity and metabolic syndrome (MeS).

Materials and Methods: Fifty-two adults undergoing diagnostic upper endoscopy were prospectively enrolled. sIAP and tIAP levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA), and intestinal IAP expression was assessed by Western blotting. Participants were classified according to body mass index (BMI) and MeS status.

Results: Both sIAP and tIAP levels showed strong inverse correlations with BMI (P < .01) and waist circumference. Obese individuals exhibited significantly lower IAP levels than normal-weight participants (P < .001). tIAP levels were significantly lower in subjects with MeS. Western blot analysis confirmed reduced IAP expression in obese individuals (P = .0139).

Conclusion: Reduced systemic and local IAP levels are associated with obesity and MeS, suggesting that IAP may serve as a potential biomarker for metabolic disease.

 

Cite this article as: Uysal A, Danış N, Şenkaya A, et al. The relationship between obesity and intestinal alkaline phosphatase: A clinical and biochemical study. Turk J Gastroenterol. 2026;37(8):858-868.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 37 · Issue 8
Pages 858-868
DOI 10.5152/tjg.2026.26008
History
Published Online June 5, 2026
License
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Affiliations
Alper Uysal ORCID
Department of Gastroenterology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Türkiye
Nilay Danış ORCID
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Ali Şenkaya ORCID
Department of Gastroenterology, Ege University Faculty of Medicine, İzmir, Türkiye
Seymur Aslanov ORCID
Gastroenterology Outpatient Clinic, İzmir Medicalpoint Hospital, İzmir, Türkiye
Ilgın Yıldız Şimsir ORCID
Department of Endocrinology, Ege University Faculty of Medicine, İzmir, Türkiye
Güliz Armağan ORCID
Department of Biochemistry, Ege University Faculty of Pharmacy, İzmir, Türkiye
Rukiye Vardar ORCID
Department of Gastroenterology, Ege University Faculty of Medicine, İzmir, Türkiye
Cite this Article
Uysal, A., Danış, N., Şenkaya, A., Aslanov, S., Yıldız Şimsir, I., Armağan, G., & Vardar, R. (2026). The Relationship Between Obesity and Intestinal Alkaline Phosphatase: A Clinical and Biochemical Study. Turkish Journal of Gastroenterology, 37(8), 858–868. https://doi.org/10.5152/tjg.2026.26008
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