Original Article

Extracorporeal Therapies in Children with Acute Liver Failure: A Single-Center Experience

Volume 34 · Issue 1 Publish Date: November 24, 2022
Emrah Gün Ayşen Durak Edin Botan Selen Şimşek Pervane Anar Gurbanov Burak Balaban Fevzi Kahveci Hasan Özen Hacer Uçmak Fulden Aycan Zarife Kuloğlu Tanıl Kendirli
Full Text PDF
DOI

Published In

Turkish Journal of Gastroenterology

Volume 34 · Issue 1

Pages: 73-79

History

Published Online: November 24, 2022

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2022 Emrah Gün, Ayşen Durak, Edin Botan, Selen Şimşek Pervane, Anar Gurbanov, Burak Balaban, Fevzi Kahveci, Hasan Özen, Hacer Uçmak, Fulden Aycan, Zarife Kuloğlu, Tanıl Kendirli

Emrah Gün
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Ayşen Durak
Department of Pediatric Ankara University Faculty of Medicine Ankara Turkey
Edin Botan
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Selen Şimşek Pervane
Department of Pediatric Ankara University Faculty of Medicine Ankara Turkey
Anar Gurbanov
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Burak Balaban
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Fevzi Kahveci
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Hasan Özen
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Hacer Uçmak
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Fulden Aycan
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Zarife Kuloğlu
Department of Pediatric Gastroenterology Ankara University Faculty of Medicine Ankara Turkey
Tanıl Kendirli
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Gün, E., Durak, A., Botan, E., Şimşek Pervane, S., Gurbanov, A., Balaban, B., … Kendirli, T. (2022). Extracorporeal Therapies in Children with Acute Liver Failure: A Single-Center Experience. Turkish Journal of Gastroenterology, 34(1), 73–79. https://doi.org/10.5152/tjg.2022.22062
Endnote/Zotero/Mendeley (RIS) BibTeX
Full Text PDF

Abstract

Background: The aim of this study is to determine the indication, timing, and administration of extracorporeal therapies such as total plasma exchange and continuous renal replacement therapy in children with acute liver failure or acute-on-chronic liver failure. Methods: This study is conducted as a retrospective, single-center study. Between January 2016 and December 2021, pediatric acute liver failure or acute-on-chronic liver failure patients for whom total plasma exchange and/or continuous renal replacement therapy was performed were included in this study. Results: Thirty-four children with acute liver failure or acute-on-chronic liver failure were included during the study period. The children comprised 14 (41.1%) males, and the median age of the patients was 54 months (5-21). Twenty-four patients (70.6%) had pediatric acute liver failure, and 10 patients (29.4%) had acute-on-chronic liver failure. Patients’ median model for end-stage liver disease and pediatric end-stage liver disease scores were 24.7/23.5, respectively. Total plasma exchange therapy was performed on all patients whereas continuous renal replacement therapy was performed on 13 patients (38.2%). The median duration of continuous renal replacement therapy was 2.5 days (2-24). The median number of the total plasma exchange sessions was 3 (1-20). The median length of stay in pediatric intensive care unit was 4.5 (2-74) days. Eleven (32.5%) patients had 1 or more improvements in hepatic encephalopathy scores after extracorporeal therapy. Eleven (32.5%) patients died. There was a significant difference between the survivors and non-survivors with respect to levels of albumin, ammonia, pediatric risk of mortality scores, and pre-hepatic encephalopathy scores. Liver transplantation was performed in 4 of 24 pediatric acute liver failure patients, and all of them survived. Conclusion: Total plasma exchange and continuous renal replacement therapy are life-saving, and both methods may reduce morbidity and mortality, also bridging to liver transplantation. Cite this article as: Gün E, Durak A, Botan E, et al. Extracorporeal therapies in children with acute liver failure: A single-center experience. Turk J Gastroenterol. 2023; 34(1): 73-79.

Most read articles by the same author(s)

1 2 > >> 
Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 34 · Issue 1
Pages 73-79
DOI 10.5152/tjg.2022.22062
History
Published Online November 24, 2022
License
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright
Copyright (c) 2022 Emrah Gün, Ayşen Durak, Edin Botan, Selen Şimşek Pervane, Anar Gurbanov, Burak Balaban, Fevzi Kahveci, Hasan Özen, Hacer Uçmak, Fulden Aycan, Zarife Kuloğlu, Tanıl Kendirli
Affiliations
Emrah Gün
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Ayşen Durak
Department of Pediatric Ankara University Faculty of Medicine Ankara Turkey
Edin Botan
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Selen Şimşek Pervane
Department of Pediatric Ankara University Faculty of Medicine Ankara Turkey
Anar Gurbanov
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Burak Balaban
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Fevzi Kahveci
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Hasan Özen
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Hacer Uçmak
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Fulden Aycan
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Zarife Kuloğlu
Department of Pediatric Gastroenterology Ankara University Faculty of Medicine Ankara Turkey
Tanıl Kendirli
Department of Pediatric Intensive Care Ankara University Faculty of Medicine Ankara Turkey
Cite this Article
Gün, E., Durak, A., Botan, E., Şimşek Pervane, S., Gurbanov, A., Balaban, B., … Kendirli, T. (2022). Extracorporeal Therapies in Children with Acute Liver Failure: A Single-Center Experience. Turkish Journal of Gastroenterology, 34(1), 73–79. https://doi.org/10.5152/tjg.2022.22062
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX
Outlines