Published In
Turkish Journal of Gastroenterology
Volume 30 · Issue 4 · July 2019
Pages: 331-335
History
Published Online: July 25, 2019
Copyright © 2019 Serkan Yaraş, Enver Üçbilek, Osman Özdoğan, Fehmi Ateş, Engin Altıntaş, Orhan Sezgin
Serkan Yaraş
Department of Gastroenterology Mersin University School of Medicine Mersin Turkey
Enver Üçbilek
Department of Gastroenterology Mersin University School of Medicine Mersin Turkey
Osman Özdoğan
Department of Gastroenterology Mersin University School of Medicine Mersin Turkey
Fehmi Ateş
Department of Gastroenterology Mersin University School of Medicine Mersin Turkey
Engin Altıntaş
Department of Gastroenterology Mersin University School of Medicine Mersin Turkey
Orhan Sezgin
Department of Gastroenterology Mersin University School of Medicine Mersin Turkey
Yaraş, S., Üçbilek, E., Özdoğan, O., Ateş, F., Altıntaş, E., & Sezgin, O. (2019). Real-life results of treatment with ombitasvir, paritaprevir, dasabuvir, and ritonavir combination in patients with chronic renal failure infected with HCV in Turkey. Turkish Journal of Gastroenterology, 30(4), 331–335. https://doi.org/10.5152/tjg.2018.18269
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Abstract
Background/Aims: As the most common liver disease in hemodialysis patients, chronic hepatitis C (CHC) can cause cirrhosis and hepatocellular carcinoma, even increase in renal-related mortality. In Turkey, the frequency of anti-hepatitis C virus (HCV) antibodies in hemodialysis patients ranged from 31.4% to 51%. Until recently, the mainstay of the CHC treatment for these patients was pegylated interferon with potential toxicities and low sustained virological response. The 3D regimen, a combination of four drugs (ombitasvir, paritaprevir, dasabuvir, and ritonavir), has recently been used for patients with chronic kidney disease infected with genotype 1a and 1b HCV. The aim of the present study was to present results of 3D treatment for patients with hemodialysis-dependent chronic renal failure (CRF) who were chronically infected with HCV.
Materials and Methods: Overall, 25 patients with hemodialysis-dependent CRF who were infected with genotype 1a/1b HCV have been treated using the 3D regimen in our gastroenterology clinic between July 2016 and October 2017. Three patients were administered additional ribavirin 200 mg/day. Serum HCV RNAs, blood chemistry, blood count, and side effects were recorded at 0, 4, and 12 weeks.
Results: All 25 patients completed and well tolerated their planned treatment. At the end of 4 weeks, the viral response (defined as HCV RNA clearance) rate was 92%. At the end of 12 weeks of treatment and 3 months after treatment, viral response rates were both 100%.
Conclusion: We observed that the treatment with 3D regimen in hemodialysis patients infected with genotype 1 hepatitis C is highly effective and well tolerated.
Cite this article as: Yaraş S, Üçbilek E, Özdoğan O, Ateş F, Altıntaş E, Sezgin O. Real-life results of treatment with ombitasvir, paritaprevir, dasabuvir, and ritonavir combination in patients with chronic renal failure infected with HCV in Turkey. Turk J Gastroenterol 2019; 30(4): 331-5.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 30 · Issue 4 · July 2019
Pages
331-335
History
Published Online
July 25, 2019
Copyright
Copyright (c) 2019 Serkan Yaraş, Enver Üçbilek, Osman Özdoğan, Fehmi Ateş, Engin Altıntaş, Orhan Sezgin
Affiliations
1
Serkan Yaraş
Department of Gastroenterology Mersin University School of Medicine Mersin Turkey
2
Enver Üçbilek
Department of Gastroenterology Mersin University School of Medicine Mersin Turkey
3
Osman Özdoğan
Department of Gastroenterology Mersin University School of Medicine Mersin Turkey
4
Fehmi Ateş
Department of Gastroenterology Mersin University School of Medicine Mersin Turkey
5
Engin Altıntaş
Department of Gastroenterology Mersin University School of Medicine Mersin Turkey
6
Orhan Sezgin
Department of Gastroenterology Mersin University School of Medicine Mersin Turkey
Cite this Article
Yaraş, S., Üçbilek, E., Özdoğan, O., Ateş, F., Altıntaş, E., & Sezgin, O. (2019). Real-life results of treatment with ombitasvir, paritaprevir, dasabuvir, and ritonavir combination in patients with chronic renal failure infected with HCV in Turkey. Turkish Journal of Gastroenterology, 30(4), 331–335. https://doi.org/10.5152/tjg.2018.18269
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