Original Article

Evaluation of Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT 1) and H19 in Determining the Diagnosis and Severity of the Disease in Patients with Acute Pancreatitis

Volume 37 · Issue 3 Publish Date: November 6, 2025
Hafize Tugba Karahan ORCID Alpaslan Tanoglu ORCID Esra Guzel Tanoglu ORCID Muhammed Said Gokce ORCID Erdem Karahan ORCID
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Turkish Journal of Gastroenterology

Volume 37 · Issue 3

Pages: 347-353

History

Published Online: November 6, 2025

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2025 Hafize Tugba Karahan, Alpaslan Tanoglu, Esra Guzel Tanoglu, Muhammed Said Gokce, Erdem Karahan

Hafize Tugba Karahan ORCID
Department of Internal Medicine, University of Health Sciences, Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital, İstanbul, Türkiye
Alpaslan Tanoglu ORCID
Department of Internal Medicine, Gastroenterology, Bahçeşehir University, İstanbul, Türkiy
Esra Guzel Tanoglu ORCID
Department of Molecular Biology and Genetics, University of Health Sciences, İstanbul, Türkiye
Muhammed Said Gokce ORCID
Department of Molecular Biology and Genetics, University of Health Sciences, İstanbul, Türkiye
Erdem Karahan ORCID
Department of Internal Medicine, University of Health Sciences, Sultan Abdulhamid Han Training and Research Hospital, İstanbul, Türkiye
Karahan, H. T., Tanoglu, A., Tanoglu, E. G., Gokce, M. S., & Karahan, E. (2025). Evaluation of Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT 1) and H19 in Determining the Diagnosis and Severity of the Disease in Patients with Acute Pancreatitis. Turkish Journal of Gastroenterology, 37(3), 347–353. https://doi.org/10.5152/tjg.2025.24701
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Abstract

Background/Aims: This current research targeted to assess whether long non-coding RNAs MALAT1 and H19, which are accepted to act a pivotal role in the progression of acute pancreatitis (AP), can be used as candidate biomarkers in addressing the diagnosis and severity of AP.

Materials and Methods: Healthy volunteers who applied to the Internal Medicine outpatient clinic between October 2022 and June 2023 and patients who were hospitalized and treated for AP in the same period were enrolled in the research. The sociodemographic charac teristics, biochemical values, and expression levels of MALAT1 and H19 of the study participants were compared.

Results: There was no difference in terms of H19 level among the patient and healthy individuals (P = .619). However, a marked upregula tion of MALAT1 expression was observed in cases of AP (P = .018). In addition, a range of biochemical markers showed notable disparities between the patient cohort and healthy individuals.

Conclusion: According to the results of this current study, because the MALAT1 levels were significantly increased in AP cases, it could be postulated that MALAT1 can be used as a candidate biomarker in AP cases in order to diagnose the illness. However, MALAT1 and H19 did not correlate with the severity of the disease.

 

Cite this article as: Karahan HT, Tanoglu A, Tanoglu EG, Gokce MS, Karahan E. Evaluation of metastasis-associated lung adenocarcinoma transcript 1 (MALAT 1) and H19 in determining the diagnosis and severity of the disease in patients with acute pancreatitis. Turk J Gastroenterol. 2026;37(3):347-353.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 37 · Issue 3
Pages 347-353
DOI 10.5152/tjg.2025.24701
History
Published Online November 6, 2025
License
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright
Copyright (c) 2025 Hafize Tugba Karahan, Alpaslan Tanoglu, Esra Guzel Tanoglu, Muhammed Said Gokce, Erdem Karahan
Affiliations
Hafize Tugba Karahan ORCID
Department of Internal Medicine, University of Health Sciences, Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital, İstanbul, Türkiye
Alpaslan Tanoglu ORCID
Department of Internal Medicine, Gastroenterology, Bahçeşehir University, İstanbul, Türkiy
Esra Guzel Tanoglu ORCID
Department of Molecular Biology and Genetics, University of Health Sciences, İstanbul, Türkiye
Muhammed Said Gokce ORCID
Department of Molecular Biology and Genetics, University of Health Sciences, İstanbul, Türkiye
Erdem Karahan ORCID
Department of Internal Medicine, University of Health Sciences, Sultan Abdulhamid Han Training and Research Hospital, İstanbul, Türkiye
Cite this Article
Karahan, H. T., Tanoglu, A., Tanoglu, E. G., Gokce, M. S., & Karahan, E. (2025). Evaluation of Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT 1) and H19 in Determining the Diagnosis and Severity of the Disease in Patients with Acute Pancreatitis. Turkish Journal of Gastroenterology, 37(3), 347–353. https://doi.org/10.5152/tjg.2025.24701
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