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Best Treatment Options for Severe Helicobacter pylori Infections

Volume 36 · Issue 12 Publish Date: June 23, 2025
Gulhan Kanat Unler Ozgur Hilal Erinanc Aydın Karakoca Huseyin Savas Gokturk
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Turkish Journal of Gastroenterology

Volume 36 · Issue 12

Pages: 807-812

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Published Online: June 23, 2025

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2025 Gulhan Kanat Unler, Ozgur Hilal Erinanc, Aydın Karakoca, Huseyin Savas Gokturk

Gulhan Kanat Unler
Department of Gastroenterology, Başkent University Faculty of Medicine, Konya, Türkiye
Ozgur Hilal Erinanc
Department of Pathology, Baskent University Faculty of Medicine, Konya, Türkiye
Aydın Karakoca
Department of Statistics, Necmettin Erbakan University Faculty of Science, Konya, Türkiye
Huseyin Savas Gokturk
Department of Gastroenterology, Başkent University Faculty of Medicine, Konya, Türkiye
Kanat Unler, G., Erinanc, O. H., Karakoca, A., & Gokturk, H. S. (2025). Best Treatment Options for Severe Helicobacter pylori Infections. Turkish Journal of Gastroenterology, 36(12), 807–812. https://doi.org/10.5152/tjg.2025.24543
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Abstract

Background/Aims :Helicobacter pylori (H. pylori) affects half of the world’s population. Increasing antibiotic resistance seems to be causing significant clinical problems. The efficacy of bismuth-containing sequential therapy with clarithromycin (BSTC), bismuth-containing sequential therapy with levofloxacin (BSTL), and bismuth-containing quadruple therapy (BQT) regimens on H. pylori eradication was investigated. The authors also investigated whether high gastric H. pylori colonization density affected treatment success through different treatment regimens.

Materials and Methods: A total of 751 H. pylori–positive patients were included retrospectively in the following treatment groups: sequential therapy with clarithromycin, sequential therapy with levofloxacin, and bismuth-containing quadruple therapy. Results: There was a significant difference between the 3 treatment protocols in terms of treatment success rates. When the success rates of the applied treatments were examined, the highest success rate was BSTL (85.3%), which was statistically significantly higher than BQT (74.8%) and BSTC (74.8%). A significant difference was found between the success rates of the protocols applied in the group with high bacterial density (P = .003). The success rates in this group were calculated as BSTL (88.6%), BQT (71.4%), and BSTC (79.4%).

Conclusion: It was concluded that BSTL may be the best option for treating H. pylori infections in first-line treatment. This regimen is particularly effective in cases of severe H. pylori colonization.

 

Cite this article as: Unler GK, Hilal Erinanc O, Karakoca A, Savas Gokturk H. Best treatment options for severe helicobacter pylori infections. Turk J Gastroenterol. 2025;36(12):807-812.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 36 · Issue 12
Pages 807-812
DOI 10.5152/tjg.2025.24543
History
Published Online June 23, 2025
License
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright
Copyright (c) 2025 Gulhan Kanat Unler, Ozgur Hilal Erinanc, Aydın Karakoca, Huseyin Savas Gokturk
Affiliations
Gulhan Kanat Unler
Department of Gastroenterology, Başkent University Faculty of Medicine, Konya, Türkiye
Ozgur Hilal Erinanc
Department of Pathology, Baskent University Faculty of Medicine, Konya, Türkiye
Aydın Karakoca
Department of Statistics, Necmettin Erbakan University Faculty of Science, Konya, Türkiye
Huseyin Savas Gokturk
Department of Gastroenterology, Başkent University Faculty of Medicine, Konya, Türkiye
Cite this Article
Kanat Unler, G., Erinanc, O. H., Karakoca, A., & Gokturk, H. S. (2025). Best Treatment Options for Severe Helicobacter pylori Infections. Turkish Journal of Gastroenterology, 36(12), 807–812. https://doi.org/10.5152/tjg.2025.24543
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