Original Article

Gasdermin D: A New Inflammatory Biomarker in Assessing Clinical Disease Activity in Crohn’s Disease

Volume 36 · Issue 9 Publish Date: May 20, 2025
Osman Cagin Buldukoglu ORCID Serkan Ocal ORCID Galip Egemen Atar ORCID Besir Kaya ORCID Muhammet Devran Isik ORCID Gul Aydin Tigli ORCID Serdar Akca ORCID Ferda Akbay Harmandar ORCID Yesim Cekin ORCID Ayhan Hilmi Cekin ORCID
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Published In

Turkish Journal of Gastroenterology

Volume 36 · Issue 9

Pages: 556-562

History

Published Online: May 20, 2025

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2025 Osman Cagin Buldukoglu, Serkan Ocal, Galip Egemen Atar, Besir Kaya, Muhammet Devran Isik, Gul Aydin Tigli, Serdar Akca, Ferda Akbay Harmandar, Yesim Cekin, Ayhan Hilmi Cekin

Osman Cagin Buldukoglu ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Serkan Ocal ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Galip Egemen Atar ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Besir Kaya ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Muhammet Devran Isik ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Gul Aydin Tigli ORCID
Department of Medical Microbiology, Antalya Training and Research Hospital, Antalya, Türkiye
Serdar Akca ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Ferda Akbay Harmandar ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Yesim Cekin ORCID
Department of Medical Microbiology, Antalya Training and Research Hospital, Antalya, Türkiye
Ayhan Hilmi Cekin ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Buldukoglu, O. C., Ocal, S., Atar, G. E., Kaya, B., Isik, M. D., Aydin Tigli, G., … Cekin, A. H. (2025). Gasdermin D: A New Inflammatory Biomarker in Assessing Clinical Disease Activity in Crohn’s Disease. Turkish Journal of Gastroenterology, 36(9), 556–562. https://doi.org/10.5152/tjg.2025.24726
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Abstract

Background/Aims: Crohn’s disease (CD) is an inflammatory, progressive disorder requiring monitoring of treatment response and disease course. Gasdermin D (GSDMD), a protein belonging to the gasdermin protein family, plays a role in inflammatory cell death, and activation of GSDMD has been shown to be a component of the pathogenesis of inflammatory bowel disease. Considering the role that GSDMD plays in inflammation, it was hypothesized that disease activity in CD may be correlated with serum GSDMD levels. The aim of this study was to assess the strength of GSDMD in predicting clinical disease activity in patients with CD in a prompt and easy manner.

Materials and Methods: This cross-sectional study was conducted over a span of 22 months from September 2022 to June 2024. A total of 61 patients with CD were included in the study. Demographic data, disease- and treatment-related data, and laboratory workups of the patients were recorded and analyzed.

Results: Gasdermin D levels were statistically significant in their correlation with the Harvey–Bradshaw Index (HBI) scores of the study population (P = .019). A threshold value of 5 ng/mL for GSDMD had a sensitivity of 84.6% and a specificity of 91.7% in differentiating patients with remission or mild disease from those with moderate or severe disease, according to HBI.

Conclusion: This pioneering study revealed that serum GSDMD can be used as a biomarker to assess clinical disease activity in patients with CD. Future studies incorporating colonoscopic evaluation into the equation will provide more insight into the use of this protein as a surrogate marker of disease progression in CD.

 

Cite this article as: Buldukoglu OC, Ocal S, Atar GE, et al. Gasdermin D: A new inflammatory biomarker in assessing clinical disease activity in Crohn’s disease. Turk J Gastroenterol. 2025;36(9):556-562.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 36 · Issue 9
Pages 556-562
DOI 10.5152/tjg.2025.24726
History
Published Online May 20, 2025
License
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright
Copyright (c) 2025 Osman Cagin Buldukoglu, Serkan Ocal, Galip Egemen Atar, Besir Kaya, Muhammet Devran Isik, Gul Aydin Tigli, Serdar Akca, Ferda Akbay Harmandar, Yesim Cekin, Ayhan Hilmi Cekin
Affiliations
Osman Cagin Buldukoglu ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Serkan Ocal ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Galip Egemen Atar ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Besir Kaya ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Muhammet Devran Isik ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Gul Aydin Tigli ORCID
Department of Medical Microbiology, Antalya Training and Research Hospital, Antalya, Türkiye
Serdar Akca ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Ferda Akbay Harmandar ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Yesim Cekin ORCID
Department of Medical Microbiology, Antalya Training and Research Hospital, Antalya, Türkiye
Ayhan Hilmi Cekin ORCID
Department of Gastroenterology, Antalya Training and Research Hospital, Antalya, Türkiye
Cite this Article
Buldukoglu, O. C., Ocal, S., Atar, G. E., Kaya, B., Isik, M. D., Aydin Tigli, G., … Cekin, A. H. (2025). Gasdermin D: A New Inflammatory Biomarker in Assessing Clinical Disease Activity in Crohn’s Disease. Turkish Journal of Gastroenterology, 36(9), 556–562. https://doi.org/10.5152/tjg.2025.24726
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