Published In
Turkish Journal of Gastroenterology
Volume 33 · Issue 6
Pages: 463-469
History
Published Online: June 15, 2022
Copyright © 2022 Sami Evirgen, Raim İliaz, Filiz Akyüz, Bilger Çavuş, Suut Göktürk, Aslı Örmeci, Özlem Mutluay Soyer, Bülent Baran, Binnur Pınarbaşı, Çetin Karaca, Kadir Demir, Fatih Beşışık, Sabahattin Kaymakoğlu
Sami Evirgen
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Raim İliaz
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Filiz Akyüz
Covering the Cover Editor
Bilger Çavuş
Department of Internal Medicine, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Suut Göktürk
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Aslı Örmeci
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Özlem Mutluay Soyer
Clinic of Gastroenterology, Tekirdağ State Hospital, Tekirdağ, Turkey
Bülent Baran
Department of Gastroenterology, Van Region Training and Research Hospital, Van, Turkey
Binnur Pınarbaşı
Departments of Gastroenterohepatology, İstanbul University İstanbul Medical Faculty, İstanbul
Çetin Karaca
Department of Gastroenterohepatology, İstanbul University, İstanbul Faculty of Medicine, İstanbul
Kadir Demir
İstanbul Üniversitesi, İstanbul Tıp Fakültesi Gastroenteropatoloji Bilim Dalı ve Patoloji anabilim Dalı, İstanbul
Fatih Beşışık
Departments of Gastroenterohepatology, İstanbul University İstanbul Medical Faculty, İstanbul
Sabahattin Kaymakoğlu
Department of Gastroenterology, İstanbul University, İstanbul School of Medicine, İstanbul
Evirgen, S., İliaz, R., Akyüz, F., Çavuş, B., Göktürk, S., Örmeci, A., … Kaymakoğlu, S. (2022). Cyclosporine Therapy as a Rescue Treatment in Steroid Refractory Acute Severe Ulcerative Colitis: A Real Life Data From a Tertiary Center. Turkish Journal of Gastroenterology, 33(6), 463–469. https://doi.org/10.5152/tjg.2022.21093
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Abstract
Background: Cyclosporine is a rescue treatment alternative to avoid colectomy in corticosteroid refractory acute severe ulcerative colitis. In this study, we aimed to evaluate the long-term efficacy and safety of cyclosporine therapy in acute severe ulcerative colitis patients. Methods: Acute severe ulcerative colitis (basal Lichtiger score > 10) patients who did not respond to 40 mg intravenous methylpredniso- lone therapy after 3-5 days were included in the study. The presence of clinical response and remission was assessed at 1st week, 1st, 6th, and 12th month according to the Lichtiger index. Results: In this study, 40 patients, whose steroid refractory acute severe ulcerative colitis and basal Lichtiger score > 10 points were enrolled. The median disease duration was 49.3 months (2-204). All patients received cyclosporine for 132 ± 78 days (7-270). Clinical response was obtained on seventh day in 82.5%. The clinical response rates of the first and sixth months were 72.5% and 62.5%, respectively. A total of 17/40 (42.5%) patients underwent colectomy within 1 year. In the patients who underwent colectomy, the basal LS (14.2 ± 1.9 vs 12.3 ± 1.7) (P = .002) was higher and the basal hemoglobin value (11.8 ± 2.3 vs 10.1 ± 1.5) (P = .037) was lower than those who did not undergo colectomy. Conclusion: Our findings suggest that cyclosporine treatment may be successfully and safely used in steroid refractory acute severe ulcerative colitis patients. Cyclosporine is a drug that has recently started to come up again with the introduction of new maintenance treatments. Especially in patients who develop a loss of response to infliximab therapy, or where infliximab therapy is contraindicated, or who have azathioprine intolerance, or are unresponsive. Cite this article as: Evirgen S, İliaz R, Akyüz F, et al. Cyclosporine therapy as a rescue treatment in steroid refractory acute severe ulcerative colitis: A real life data from a tertiary center. Turk J Gastroenterol. 2022;33(6):463-469.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 33 · Issue 6
Pages
463-469
History
Published Online
June 15, 2022
Copyright
Copyright (c) 2022 Sami Evirgen, Raim İliaz, Filiz Akyüz, Bilger Çavuş, Suut Göktürk, Aslı Örmeci, Özlem Mutluay Soyer, Bülent Baran, Binnur Pınarbaşı, Çetin Karaca, Kadir Demir, Fatih Beşışık, Sabahattin Kaymakoğlu
Affiliations
Sami Evirgen
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Raim İliaz
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Filiz Akyüz
Covering the Cover Editor
Bilger Çavuş
Department of Internal Medicine, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Suut Göktürk
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Aslı Örmeci
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Özlem Mutluay Soyer
Clinic of Gastroenterology, Tekirdağ State Hospital, Tekirdağ, Turkey
Bülent Baran
Department of Gastroenterology, Van Region Training and Research Hospital, Van, Turkey
Binnur Pınarbaşı
Departments of Gastroenterohepatology, İstanbul University İstanbul Medical Faculty, İstanbul
Çetin Karaca
Department of Gastroenterohepatology, İstanbul University, İstanbul Faculty of Medicine, İstanbul
Kadir Demir
İstanbul Üniversitesi, İstanbul Tıp Fakültesi Gastroenteropatoloji Bilim Dalı ve Patoloji anabilim Dalı, İstanbul
Fatih Beşışık
Departments of Gastroenterohepatology, İstanbul University İstanbul Medical Faculty, İstanbul
Sabahattin Kaymakoğlu
Department of Gastroenterology, İstanbul University, İstanbul School of Medicine, İstanbul
Cite this Article
Evirgen, S., İliaz, R., Akyüz, F., Çavuş, B., Göktürk, S., Örmeci, A., … Kaymakoğlu, S. (2022). Cyclosporine Therapy as a Rescue Treatment in Steroid Refractory Acute Severe Ulcerative Colitis: A Real Life Data From a Tertiary Center. Turkish Journal of Gastroenterology, 33(6), 463–469. https://doi.org/10.5152/tjg.2022.21093
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