Pancreatobiliary - Original Article

Mucin Expression in Mucinous Pancreatic Cysts: Can String Sign Test Predict Mucin Types? A Single Center Pilot Study

Volume 32 · Issue 2 Publish Date: February 15, 2021
İbrahim Hakkı Köker Nurcan Ünver Fatma Ümit Malya Ömer Uysal Elmas Biberci Keskin Hakan Şentürk
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Turkish Journal of Gastroenterology

Volume 32 · Issue 2

Pages: 187-193

History

Published Online: February 15, 2021

Copyright © 2021 İbrahim Hakkı Köker, Nurcan Ünver, Fatma Ümit Malya, Ömer Uysal, Elmas Biberci Keskin, Hakan Şentürk

İbrahim Hakkı Köker
Department of Gastroenterology, Okmeydanı Research and Education Hospital, İstanbul, Turkey
Nurcan Ünver
Department of Pathology, Bezmialem Vakif University Faculty of Medicine, İstanbul, Turkey
Fatma Ümit Malya
Department of General Surgery, Bezmialem Vakif University Faculty of Medicine, İstanbul, Turkey
Ömer Uysal
Department of Biostatistics, Bezmialem Vakıf University, Faculty of Medicine, İstanbul, Turkey
Elmas Biberci Keskin
Department of Gastroenterology, Bezmialem Vakıf University School of Medicine, İstanbul, Turkey
Hakan Şentürk
Department of Gastroenterology, Bezmialem Vakıf University Faculty of Medicine, İstanbul, Turkey
Köker, İbrahim H., Ünver, N., Malya, F. Ümit, Uysal, Ömer, Biberci Keskin, E., & Şentürk, H. (2021). Mucin Expression in Mucinous Pancreatic Cysts: Can String Sign Test Predict Mucin Types? A Single Center Pilot Study. Turkish Journal of Gastroenterology, 32(2), 187–193. https://doi.org/10.5152/tjg.2020.20060
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Abstract

Background/Aims: Mucinous pancreatic cystic lesions (PCLs) express different mucin types according to their histomorphologic types. High cystic fluid viscosity may help for detection of mucinous PCLs. We hypothesized that if high cystic fluid viscosity may be suggestive of a certain mucin (MUC) type in mucinous PCLs. Materials and Methods: Prespecified MUC types (MUC1, MUC2, MUC4, MUC5AC and MUC6) were evaluated in 18 definitively diagnosed mucinous PCLs with sufficient tissue material and prediagnostic cyst fluid viscosity evaluation -String Sign (SS)- test. We evaluated the agreement of MUC expression with positive SS test results. Later, we compared cystic fluid carcinoembryonic antigen (CEA) between the prespecified MUC expressing and nonexpressing cyst types. Results: A total of 18 mucinous PCL patients, 11 females, with mean age ± SD (59.7 ± 13.3) were included. Almost all malignant mucinous PCLs expressed MUC1 (71.4 %) (P=0.023). We found no significant agreement between the prespecified MUC types and positive SS, except MUC4 which had a mild agreement. Also, no significant relation was found between cystic fluid CEA levels and MUC expression (p=0.584). Conclusion: We did not detect a significantly moderate or good agreement between the prespecified MUC types and SS test. MUC1 was highly expressed in malignant mucinous cysts however, it was incompatible with the SS test. MUC4 expression showed a mild agreement with SS test in a small number of patients. Cite this article as: Köker İH, Ünver N, Ümit Malya F, Uysal Ö, Biberci Keskin E, Şentürk H. Mucin expression in mucinous pancreatic cysts: Can string sign test predict mucin types? A single center pilot study. Turk J Gastroenterol 7 December 2020. 10.5152/tjg.2020.20060.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 32 · Issue 2
Pages 187-193
DOI 10.5152/tjg.2020.20060
History
Published Online February 15, 2021
Copyright
Copyright (c) 2021 İbrahim Hakkı Köker, Nurcan Ünver, Fatma Ümit Malya, Ömer Uysal, Elmas Biberci Keskin, Hakan Şentürk
Affiliations
İbrahim Hakkı Köker
Department of Gastroenterology, Okmeydanı Research and Education Hospital, İstanbul, Turkey
Nurcan Ünver
Department of Pathology, Bezmialem Vakif University Faculty of Medicine, İstanbul, Turkey
Fatma Ümit Malya
Department of General Surgery, Bezmialem Vakif University Faculty of Medicine, İstanbul, Turkey
Ömer Uysal
Department of Biostatistics, Bezmialem Vakıf University, Faculty of Medicine, İstanbul, Turkey
Elmas Biberci Keskin
Department of Gastroenterology, Bezmialem Vakıf University School of Medicine, İstanbul, Turkey
Hakan Şentürk
Department of Gastroenterology, Bezmialem Vakıf University Faculty of Medicine, İstanbul, Turkey
Cite this Article
Köker, İbrahim H., Ünver, N., Malya, F. Ümit, Uysal, Ömer, Biberci Keskin, E., & Şentürk, H. (2021). Mucin Expression in Mucinous Pancreatic Cysts: Can String Sign Test Predict Mucin Types? A Single Center Pilot Study. Turkish Journal of Gastroenterology, 32(2), 187–193. https://doi.org/10.5152/tjg.2020.20060
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