Liver - Original Article

Growing burden of nonalcoholic fatty liver disease in Turkey: A single-center experience

Volume 30 · Issue 10 Publish Date: October 15, 2019
Yusuf Yılmaz Haluk Tarık Kanı Coşkun Özer Demirtaş Eda Kaya Aybüke Fatma Sapmaz Lubna Qutranji Tasnim Alkayyali Kerim Deniz Batun Mahmut Batman Berk Toy Aslı Çiftaslan
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Published In

Turkish Journal of Gastroenterology

Volume 30 · Issue 10

Pages: 892-898

History

Published Online: October 15, 2019

Copyright © 2019 Yusuf Yılmaz, Haluk Tarık Kanı, Coşkun Özer Demirtaş, Eda Kaya, Aybüke Fatma Sapmaz, Lubna Qutranji, Tasnim Alkayyali, Kerim Deniz Batun, Mahmut Batman, Berk Toy, Aslı Çiftaslan

Yusuf Yılmaz
Department of Gastroenterology, Marmara University Faculty of Medicine, İstanbul, Turkey; Marmara University Gastroenterology Institute, İstanbul, Turkey
Haluk Tarık Kanı
Department of Gastroenterology, Marmara University School of Medicine, İstanbul, Turkey
Coşkun Özer Demirtaş
Department of Gastroenterology, Marmara University School of Medicine, İstanbul, Turkey
Eda Kaya
Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine, Turkey
Aybüke Fatma Sapmaz
Marmara University School of Medicine, İstanbul, Turkey
Lubna Qutranji
-Marmara University School of Medicine, İstanbul, Turkey
Tasnim Alkayyali
-Marmara University School of Medicine, İstanbul, Turkey
Kerim Deniz Batun
-Marmara University School of Medicine, İstanbul, Turkey
Mahmut Batman
-Marmara University School of Medicine, İstanbul, Turkey
Berk Toy
-Marmara University School of Medicine, İstanbul, Turkey
Aslı Çiftaslan
-Marmara University School of Medicine, İstanbul, Turkey
Yılmaz, Y., Kanı, H. T., Demirtaş, C. Özer, Kaya, E., Sapmaz, A. F., Qutranji, L., … Çiftaslan, A. (2019). Growing burden of nonalcoholic fatty liver disease in Turkey: A single-center experience. Turkish Journal of Gastroenterology, 30(10), 892–898. https://doi.org/10.5152/tjg.2019.19072
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Abstract

Background/Aims: Nonalcoholic fatty liver disease (NAFLD), which consists of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH), is a growing epidemic in Turkey, considering the recent alarming prevalence of 48.3%. Patients with NASH and/or liver fibrosis are more likely to progress to advanced liver disease. In this single-center study, we sought to describe the clinical and histological characteristics of a sample of Turkish patients with biopsy-proven NAFLD, who were enrolled over a 4-year period. Materials and Methods: This is a retrospective analysis of prospectively collected data from a total of 468 patients (224 males, 244 females; median age, 47 [18-71]. The study cohort consisted of patients with biopsy-proven NAFLD who were followed up at our outpatient clinic from 2009 to 2010 and from 2017 to 2018. Histological classification of the biopsies was performed according to the Steatosis, Activity and Fibrosis (SAF) scoring allowing the use of Fatty Liver Inhibition of Progression (FLIP) algorithm and the NAFLD Activity Score (NAS) scoring system. Results: Based on the SAF scoring, most patients (90.4%) had biopsy-proven NASH, whereas the NAFL was much rarer (9.6%). The prevalence of significant fibrosis (≥F2), advanced fibrosis (≥F3), and cirrhosis (F=4) was 35.0%, 17.5%, and 3.8%, respectively. The percentage of lean, overweight, and obese patients with NAFLD was 6.4%, 32.6%, and 61%, respectively. Metabolic syndrome was prevalent in 63% of the patients and Type 2 diabetes mellitus in 33.5%. Conclusion: The growing burden of NAFLD as a public health problem in Turkey is underscored by its marked histological severity in terms of NASH and fibrosis. Well-conducted clinical trials will be essential for slowing down the NASH progression.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 30 · Issue 10
Pages 892-898
DOI 10.5152/tjg.2019.19072
History
Published Online October 15, 2019
Copyright
Copyright (c) 2019 Yusuf Yılmaz, Haluk Tarık Kanı, Coşkun Özer Demirtaş, Eda Kaya, Aybüke Fatma Sapmaz, Lubna Qutranji, Tasnim Alkayyali, Kerim Deniz Batun, Mahmut Batman, Berk Toy, Aslı Çiftaslan
Affiliations
Yusuf Yılmaz
Department of Gastroenterology, Marmara University Faculty of Medicine, İstanbul, Turkey; Marmara University Gastroenterology Institute, İstanbul, Turkey
Haluk Tarık Kanı
Department of Gastroenterology, Marmara University School of Medicine, İstanbul, Turkey
Coşkun Özer Demirtaş
Department of Gastroenterology, Marmara University School of Medicine, İstanbul, Turkey
Eda Kaya
Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine, Turkey
Aybüke Fatma Sapmaz
Marmara University School of Medicine, İstanbul, Turkey
Lubna Qutranji
-Marmara University School of Medicine, İstanbul, Turkey
Tasnim Alkayyali
-Marmara University School of Medicine, İstanbul, Turkey
Kerim Deniz Batun
-Marmara University School of Medicine, İstanbul, Turkey
Mahmut Batman
-Marmara University School of Medicine, İstanbul, Turkey
Berk Toy
-Marmara University School of Medicine, İstanbul, Turkey
Aslı Çiftaslan
-Marmara University School of Medicine, İstanbul, Turkey
Cite this Article
Yılmaz, Y., Kanı, H. T., Demirtaş, C. Özer, Kaya, E., Sapmaz, A. F., Qutranji, L., … Çiftaslan, A. (2019). Growing burden of nonalcoholic fatty liver disease in Turkey: A single-center experience. Turkish Journal of Gastroenterology, 30(10), 892–898. https://doi.org/10.5152/tjg.2019.19072
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