Published In
Turkish Journal of Gastroenterology
Volume 29 · Issue 4
Pages: 384-391
History
Published Online: July 15, 2018
Copyright © 2018 Raim İliaz, Filiz Akyüz, Gülçin Yeğen, Aslı Örmeci, Suut Göktürk, Ümit Akyüz, Bülent Baran, Özlem Mutluay, Sami Evirgen, Çetin Karaca, Kadir Demir, Fatih Beşışık, Mine Güllüoğlu, Sabahattin Kaymakoğlu
Raim İliaz
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Filiz Akyüz
Covering the Cover Editor
Gülçin Yeğen
Department of Pathology, İstanbul University Faculty of Medicine, İstanbul, Turkey
Aslı Örmeci
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Suut Göktürk
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Ümit Akyüz
Department of Gastroenterology, Yeditepe University Faculty of Medicine, İstanbul, Turkey
Bülent Baran
Department of Gastroenterology, Van Region Training and Research Hospital, Van, Turkey
Özlem Mutluay
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Sami Evirgen
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Çetin Karaca
Department of Gastroenterohepatology, İstanbul University, İstanbul Faculty of Medicine, İstanbul
Kadir Demir
İstanbul Üniversitesi, İstanbul Tıp Fakültesi Gastroenteropatoloji Bilim Dalı ve Patoloji anabilim Dalı, İstanbul
Fatih Beşışık
Departments of Gastroenterohepatology, İstanbul University İstanbul Medical Faculty, İstanbul
Mine Güllüoğlu
Departments of Pathology, İstanbul University İstanbul Medical Faculty, İstanbul
Sabahattin Kaymakoğlu
Department of Gastroenterology, İstanbul University, İstanbul School of Medicine, İstanbul
İliaz, R., Akyüz, F., Yeğen, G., Örmeci, A., Göktürk, S., Akyüz, Ümit, … Kaymakoğlu, S. (2018). Does the number of mucosal immune cells differ in irritable bowel syndrome and its subtypes?. Turkish Journal of Gastroenterology, 29(4), 384–391. https://doi.org/10.5152/tjg.2018.17491
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Abstract
Abstract Background/Aims: Recently, mucosal inflammation has been proposed to be one of the mechanisms underlying the pathophysiology of irritable bowel syndrome (IBS); however, there are controversial results regarding this hypotheses. Our aim was to evaluate immune cell infiltration in rectal and ileal biopsy specimens of patients with IBS and to compare it with those of healthy controls. Materials and Methods: In total, 36 patients with IBS (15 with diarrhea and 21 with constipation) and 16 healthy volunteers were enrolled. Ileocolonoscopy and ileal/rectal biopsies were performed. Rectal and terminal ileal biopsy specimens were evaluated for mucosal immune cell infiltration using immunohistochemical analysis. Serotonin positivity as well as counts of intraepithelial lymphocytes (IEL) and CD4+, CD8+, CD20+, and CD3+ cells were determined by a single pathologist who is an expert in the gastrointestinal system. Results: CD3+ and CD4+ cell counts in rectal and terminal ileal biopsy specimens were lower in the IBS group than in the controls. Conversely, there was no statistically significant difference between the IBS and control groups in terms of serotonin positivity as well as counts of IEL and CD20+ and CD8+ cells. Comparison between the IBS subgroups revealed a higher number of IEL in rectal biopsy specimens of the diarrhea dominant group. In the IBS subgroups, immune cell counts in terminal ileal and rectal biopsy specimens showed a positive correlation. Conclusion: IBS and its subgroups showed lower immune cell counts than the controls in our study. These results indicate that there is no significant mucosal inflammation in homogeneous groups of patients with IBS. Rectal biopsies may be sufficient for the evaluation of inflammation in IBS. Cite this article as: İliaz R, Akyüz F, Yeğen G, et al. Does the number of mucosal immune cells differ in irritable bowel syndrome and its subtypes? Turk J Gastroenterol 2018; 29: 384-91.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 29 · Issue 4
Pages
384-391
History
Published Online
July 15, 2018
Copyright
Copyright (c) 2018 Raim İliaz, Filiz Akyüz, Gülçin Yeğen, Aslı Örmeci, Suut Göktürk, Ümit Akyüz, Bülent Baran, Özlem Mutluay, Sami Evirgen, Çetin Karaca, Kadir Demir, Fatih Beşışık, Mine Güllüoğlu, Sabahattin Kaymakoğlu
Affiliations
Raim İliaz
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Filiz Akyüz
Covering the Cover Editor
Gülçin Yeğen
Department of Pathology, İstanbul University Faculty of Medicine, İstanbul, Turkey
Aslı Örmeci
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Suut Göktürk
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Ümit Akyüz
Department of Gastroenterology, Yeditepe University Faculty of Medicine, İstanbul, Turkey
Bülent Baran
Department of Gastroenterology, Van Region Training and Research Hospital, Van, Turkey
Özlem Mutluay
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Sami Evirgen
Department of Gastroenterology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey
Çetin Karaca
Department of Gastroenterohepatology, İstanbul University, İstanbul Faculty of Medicine, İstanbul
Kadir Demir
İstanbul Üniversitesi, İstanbul Tıp Fakültesi Gastroenteropatoloji Bilim Dalı ve Patoloji anabilim Dalı, İstanbul
Fatih Beşışık
Departments of Gastroenterohepatology, İstanbul University İstanbul Medical Faculty, İstanbul
Mine Güllüoğlu
Departments of Pathology, İstanbul University İstanbul Medical Faculty, İstanbul
Sabahattin Kaymakoğlu
Department of Gastroenterology, İstanbul University, İstanbul School of Medicine, İstanbul
Cite this Article
İliaz, R., Akyüz, F., Yeğen, G., Örmeci, A., Göktürk, S., Akyüz, Ümit, … Kaymakoğlu, S. (2018). Does the number of mucosal immune cells differ in irritable bowel syndrome and its subtypes?. Turkish Journal of Gastroenterology, 29(4), 384–391. https://doi.org/10.5152/tjg.2018.17491
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