Basic & Translational - Original Article

Methylprednisolone prevents bacterial translocation in thioacetamide-induced liver failure in rats

Volume 28 · Issue 5 Publish Date: September 15, 2017
Murat Muhsin Muhip Harputluoğlu İsmail Temel Ulvi Demirel Yüksel Seçkin Murat Aladağ Barış Otlu Neşe Karadağ Fatma Özyalın Nilay Aydoğan Engin Burak Selçuk
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Turkish Journal of Gastroenterology

Volume 28 · Issue 5

Pages: 394-400

History

Published Online: September 15, 2017

Copyright © 2017 Murat Muhsin Muhip Harputluoğlu, İsmail Temel, Ulvi Demirel, Yüksel Seçkin, Murat Aladağ, Barış Otlu, Neşe Karadağ, Fatma Özyalın, Nilay Aydoğan, Engin Burak Selçuk

Murat Muhsin Muhip Harputluoğlu
Department of Gastroenterology, İnönü University School of Medicine, Malatya, Turkey
İsmail Temel
Department of Biochemistry, İnönü University School of Medicine, Malatya, Turkey
Ulvi Demirel
Department of Gastroenterology, Elazığ Training and Research Hospital, Elazığ, Turkey
Yüksel Seçkin
Department of Gastroenterology, İnönü University School of Medicine, Malatya, Turkey
Murat Aladağ
Department of Gastroenterology, İnönü University School of Medicine, Malatya, Turkey
Barış Otlu
Department of Microbiology, İnönü University School of Medicine, Malatya, Turkey
Neşe Karadağ
Department of Pathology, İnönü University School of Medicine, Malatya, Turkey
Fatma Özyalın
Department of Biochemistry, İnönü University School of Medicine, Malatya, Turkey
Nilay Aydoğan
Department of Biochemistry, İnönü University School of Medicine, Malatya, Turkey
Engin Burak Selçuk
Department of Family Medicine, İnönü University School of Medicine, Malatya, Turkey
Harputluoğlu, M. M. M., Temel, İsmail, Demirel, U., Seçkin, Y., Aladağ, M., Otlu, B., … Selçuk, E. B. (2017). Methylprednisolone prevents bacterial translocation in thioacetamide-induced liver failure in rats. Turkish Journal of Gastroenterology, 28(5), 394–400. https://doi.org/10.5152/tjg.2017.1775
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Abstract

Abstract Background/Aims: Steroids have been shown to prevent intestinal oxidative stress. We investigated the effects of methylprednisolone on intestinal oxidative damage and bacterial translocation in thioacetamide-induced liver failure in rats. Materials and Methods: Group 1 (n=8) was the control group. In group 2 (n=8), the thioacetamide group, rats received 300 mg/kg intraperitoneal thioacetamide daily for 2 days. In group 3 (n=8), the thioacetamide+methylprednisolone group, treatment with methylprednisolone (30 mg/kg intraperitoneal) was commenced 48 h before the first dose of thioacetamide. In group 4 (n=8), the methylprednisolone group, the rats received only methylprednisolone (30 mg/kg intraperitoneal). Results: Serious hepatic and intestinal oxidative damage and high bacterial translocation frequencies were observed in the thioacetamide group compared with those of the controls. Bacterial translocation frequency in the thioacetamide+methylprednisolone group was significantly lower than that in the thioacetamide group (p Conclusion: Our findings suggest that methylprednisolone reduces bacterial translocation by preventing intestinal oxidative damage in this model of acute liver failure in rats. Cite this article as: Harputluoğlu MMM, Temel İ, Demirel U, et al. Methylprednisolone prevents bacterial translocation in thioacetamide-induced liver failure in rats. Turk J Gastroenterol 2017; 28: 394-400.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 28 · Issue 5
Pages 394-400
DOI 10.5152/tjg.2017.1775
History
Published Online September 15, 2017
Copyright
Copyright (c) 2017 Murat Muhsin Muhip Harputluoğlu, İsmail Temel, Ulvi Demirel, Yüksel Seçkin, Murat Aladağ, Barış Otlu, Neşe Karadağ, Fatma Özyalın, Nilay Aydoğan, Engin Burak Selçuk
Affiliations
Murat Muhsin Muhip Harputluoğlu
Department of Gastroenterology, İnönü University School of Medicine, Malatya, Turkey
İsmail Temel
Department of Biochemistry, İnönü University School of Medicine, Malatya, Turkey
Ulvi Demirel
Department of Gastroenterology, Elazığ Training and Research Hospital, Elazığ, Turkey
Yüksel Seçkin
Department of Gastroenterology, İnönü University School of Medicine, Malatya, Turkey
Murat Aladağ
Department of Gastroenterology, İnönü University School of Medicine, Malatya, Turkey
Barış Otlu
Department of Microbiology, İnönü University School of Medicine, Malatya, Turkey
Neşe Karadağ
Department of Pathology, İnönü University School of Medicine, Malatya, Turkey
Fatma Özyalın
Department of Biochemistry, İnönü University School of Medicine, Malatya, Turkey
Nilay Aydoğan
Department of Biochemistry, İnönü University School of Medicine, Malatya, Turkey
Engin Burak Selçuk
Department of Family Medicine, İnönü University School of Medicine, Malatya, Turkey
Cite this Article
Harputluoğlu, M. M. M., Temel, İsmail, Demirel, U., Seçkin, Y., Aladağ, M., Otlu, B., … Selçuk, E. B. (2017). Methylprednisolone prevents bacterial translocation in thioacetamide-induced liver failure in rats. Turkish Journal of Gastroenterology, 28(5), 394–400. https://doi.org/10.5152/tjg.2017.1775
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