Original Article

Association between single nucleotide polymorphisms in prospective genes and susceptibility to ankylosing spondylitis and inflammatory bowel disease in a single centre in Turkey

Volume 27 · Issue 4 · July 2016 Publish Date: July 15, 2016
Orhan Küçükşahin 1 Aşkın Ateş 2 Nuran Türkçapar 3 Murat Törüner 4 Murat Turgay 5 Türker Duman 6 Ali Şahin 7 Mustafa Turgut Yıldızgören 8 Alexis K. Okoh 9 Emre Külahçıoğlu 10 Şükran Erten 11 Gülay Kınıklı 12 Saeid Assadpour 13 Nurşen Düzgün 14
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Published In

Turkish Journal of Gastroenterology

Volume 27 · Issue 4 · July 2016

Pages: 317-324

History

Published Online: July 15, 2016

Copyright © 2016 Orhan Küçükşahin, Aşkın Ateş, Nuran Türkçapar, Murat Törüner, Murat Turgay, Türker Duman, Ali Şahin, Mustafa Turgut Yıldızgören, Alexis K. Okoh, Emre Külahçıoğlu, Şükran Erten, Gülay Kınıklı, Saeid Assadpour, Nurşen Düzgün

Orhan Küçükşahin
Department of Rheumatology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
Aşkın Ateş
Department of Rheumatology, Ankara University School of Medicine, Ankara, Turkey
Nuran Türkçapar
Department of Rheumatology, Ankara University School of Medicine, Ankara, Turkey
Murat Törüner
Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey
Murat Turgay
Department of Rheumatology, Ankara University School of Medicine, Ankara, Turkey
Türker Duman
Department of Allergy and Immunology, Ankara University School of Medicine, Ankara, Turkey
Ali Şahin
Department of Rheumatology, Cumhuriyet University School of Medicine, Sivas, Turkey
Mustafa Turgut Yıldızgören
Department of Physical Medicine and Rehabilitation, Mustafa Kemal University School of Medicine, Hatay, Turkey
Alexis K. Okoh
Department of Internal Medicine, Ankara University School of Medicine, Ankara, Turkey
Emre Külahçıoğlu
Department of Internal Medicine, Ankara University School of Medicine, Ankara, Turkey
Şükran Erten
Department of Rheumatology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
Gülay Kınıklı
Department of Rheumatology, Ankara University School of Medicine, Ankara, Turkey
Saeid Assadpour
Department of Allergy and Immunology, Ankara University School of Medicine, Ankara, Turkey
Nurşen Düzgün
Department of Rheumatology, Ankara University School of Medicine, Ankara, Turkey
Küçükşahin, O., Ateş, A., Türkçapar, N., Törüner, M., Turgay, M., Duman, T., … Düzgün, N. (2016). Association between single nucleotide polymorphisms in prospective genes and susceptibility to ankylosing spondylitis and inflammatory bowel disease in a single centre in Turkey. Turkish Journal of Gastroenterology, 27(4), 317–324. https://doi.org/10.5152/tjg.2016.15466
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Abstract

Abstract Background/Aims: To establish the prevalence of the single nucleotide polymorphisms (SNPs) of endoplasmic reticulum aminopeptidase 1 (ERAP1), IL-23 receptor (IL-23R), signal transducer and activator of transcription 3 (STAT-3) and Janus kinase 2 (JAK-2) in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) in a Turkish population. Materials and Methods: A total of 562 subjects who presented at the Ankara University internal medicine departments of rheumatology and gastroenterology outpatient clinics were recruited in this study, including 365 patients with AS, 197 patients with IBD and 230 healthy controls. ERAP1, IL-23R, STAT-3 and JAK-2) were genotyped in competitive allele-specific polymerase chain reactions. Results: The ERAP1 (rs26653) polymorphism was found to increase the disease risk in patients with AS and IBD compared with the control group (p=0.02 and p=0.01, respectively). In addition, this polymorphism revealed a significant relationship with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Bath AS Functional Index (BASFI) in patients with AS (r=0.829, p<0.001 and r=0.731, p<0.001, respectively). Conclusion: The ERAP1 gene polymorphism might be a risk factor in the pathogenesis of AS and IBD. In contrast, IL-23R gene polymorphisms may serve a protective role in AS and IBD.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 27 · Issue 4 · July 2016
Pages 317-324
DOI 10.5152/tjg.2016.15466
History
Published Online July 15, 2016
Copyright
Copyright (c) 2016 Orhan Küçükşahin, Aşkın Ateş, Nuran Türkçapar, Murat Törüner, Murat Turgay, Türker Duman, Ali Şahin, Mustafa Turgut Yıldızgören, Alexis K. Okoh, Emre Külahçıoğlu, Şükran Erten, Gülay Kınıklı, Saeid Assadpour, Nurşen Düzgün
Affiliations
1
Orhan Küçükşahin
Department of Rheumatology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
2
Aşkın Ateş
Department of Rheumatology, Ankara University School of Medicine, Ankara, Turkey
3
Nuran Türkçapar
Department of Rheumatology, Ankara University School of Medicine, Ankara, Turkey
4
Murat Törüner
Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey
5
Murat Turgay
Department of Rheumatology, Ankara University School of Medicine, Ankara, Turkey
6
Türker Duman
Department of Allergy and Immunology, Ankara University School of Medicine, Ankara, Turkey
7
Ali Şahin
Department of Rheumatology, Cumhuriyet University School of Medicine, Sivas, Turkey
8
Mustafa Turgut Yıldızgören
Department of Physical Medicine and Rehabilitation, Mustafa Kemal University School of Medicine, Hatay, Turkey
9
Alexis K. Okoh
Department of Internal Medicine, Ankara University School of Medicine, Ankara, Turkey
10
Emre Külahçıoğlu
Department of Internal Medicine, Ankara University School of Medicine, Ankara, Turkey
11
Şükran Erten
Department of Rheumatology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
12
Gülay Kınıklı
Department of Rheumatology, Ankara University School of Medicine, Ankara, Turkey
13
Saeid Assadpour
Department of Allergy and Immunology, Ankara University School of Medicine, Ankara, Turkey
14
Nurşen Düzgün
Department of Rheumatology, Ankara University School of Medicine, Ankara, Turkey
Cite this Article
Küçükşahin, O., Ateş, A., Türkçapar, N., Törüner, M., Turgay, M., Duman, T., … Düzgün, N. (2016). Association between single nucleotide polymorphisms in prospective genes and susceptibility to ankylosing spondylitis and inflammatory bowel disease in a single centre in Turkey. Turkish Journal of Gastroenterology, 27(4), 317–324. https://doi.org/10.5152/tjg.2016.15466
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