Original Article

Effect of H. pylori infection on gastrin, ghrelin, motilin, and gastroesophageal reflux

Volume 26 · Issue 5 Publish Date: September 15, 2015
Makbule Eren Ömer Çolak Serap Işıksoy Aslı Yavuz
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Turkish Journal of Gastroenterology

Volume 26 · Issue 5

Pages: 367-372

History

Published Online: September 15, 2015

Copyright © 2015 Makbule Eren, Ömer Çolak, Serap Işıksoy, Aslı Yavuz

Makbule Eren
Departments of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, and Pathology, Eskişehir Osmangazi University, Faculty of Medicine, Eskişehir
Ömer Çolak
Departments of Biochemistry Osmangazi University, Faculty of Medicine, Eskişehir
Serap Işıksoy
Departments of Pathology, Osmangazi University Medical Faculty, Eskisehir
Aslı Yavuz
Department of Pediatric Gastroenterology and Hepatology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey
Eren, M., Çolak, Ömer, Işıksoy, S., & Yavuz, A. (2015). Effect of H. pylori infection on gastrin, ghrelin, motilin, and gastroesophageal reflux. Turkish Journal of Gastroenterology, 26(5), 367–372. https://doi.org/10.5152/tjg.2015.0110
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Abstract

Abstract Background/Aims: To evaluate the occurrence of gastroesophageal reflux and possible mechanisms in Helicobacter pylori infection. Materials and Methods: Symptoms of H. pylori-infected children, their total gastroesophageal reflux episodes, acid exposure percentage, gastrin, ghrelin, and motilin levels were evaluated before and after H. pylori eradication. Results: Forty-two H. pylori-infected children were eligible for this study. Acid exposure % and total reflux episodes before and after H. pylori eradication were 10.2%±14.8% vs. 7.71%±5.0% and 94.7%±102.1% vs. 64.6%±55.0%, respectively (p=0.28, p=0.082). There was an insignificant change in the serum gastrin (93.4±153.8 pmol/L vs. 1.28±149.4 pmol/L, p=0.67), ghrelin (7.69±197.5 pg/mL vs. 8.36±299.5 pg/mL, p=0.274), and motilin (75.1±81.2 pg/mL vs. 97.2±80.5 pg/mL, p=0.206) levels after eradication. Gastrin and ghrelin levels were negatively correlated after H. pylori eradication (r=−0.38, p=0.031). There was no association between gastroesophageal reflux episodes and gastrin, ghrelin, and motilin levels (r=0.25 and p=0.11; r= 0.24 and p=0.13; r=-0.23 and p=0.14, respectively) Conclusion: H. pylori infection is neither protective nor harmful in the gastroesophageal reflux. Neither ghrelin nor motilin levels was associated with gastroesophageal reflux. None of gastrin, ghrelin, and motilin levels was affected by H. pylori infection. There is an inverse association between gastrin and ghrelin levels after H. pylori eradication.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 26 · Issue 5
Pages 367-372
DOI 10.5152/tjg.2015.0110
History
Published Online September 15, 2015
Copyright
Copyright (c) 2015 Makbule Eren, Ömer Çolak, Serap Işıksoy, Aslı Yavuz
Affiliations
Makbule Eren
Departments of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, and Pathology, Eskişehir Osmangazi University, Faculty of Medicine, Eskişehir
Ömer Çolak
Departments of Biochemistry Osmangazi University, Faculty of Medicine, Eskişehir
Serap Işıksoy
Departments of Pathology, Osmangazi University Medical Faculty, Eskisehir
Aslı Yavuz
Department of Pediatric Gastroenterology and Hepatology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey
Cite this Article
Eren, M., Çolak, Ömer, Işıksoy, S., & Yavuz, A. (2015). Effect of H. pylori infection on gastrin, ghrelin, motilin, and gastroesophageal reflux. Turkish Journal of Gastroenterology, 26(5), 367–372. https://doi.org/10.5152/tjg.2015.0110
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