Original Article

No association between the functional cannabinoid receptor type 2 Q63R variants and inflammatory bowel disease in Turkish subjects

Volume 25 · Issue 6 Publish Date: December 15, 2014
Oya Yonal Fatih Eren Yusuf Yılmaz Özlen Atuğ Hülya Hamzaoğlu Över
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Published In

Turkish Journal of Gastroenterology

Volume 25 · Issue 6

Pages: 639-643

History

Published Online: December 15, 2014

Copyright © 2014 Oya Yonal, Fatih Eren, Yusuf Yılmaz, Özlen Atuğ, Hülya Hamzaoğlu Över

Oya Yonal
Department of Gastroenterology, Marmara University Faculty of Medicine, İstanbul, Turkey
Fatih Eren
Department of Marmara University Institute of Gastroenterology, İstanbul
Yusuf Yılmaz
Department of Gastroenterology, Marmara University Faculty of Medicine, İstanbul, Turkey; Marmara University Gastroenterology Institute, İstanbul, Turkey
Özlen Atuğ
Department of Gastroenterology, Marmara University, School of Medicine, İstanbul
Hülya Hamzaoğlu Över
Department of Gastroenterology, Marmara University Faculty of Medicine, İstanbul, Turkey
Yonal, O., Eren, F., Yılmaz, Y., Atuğ, Özlen, & Hamzaoğlu Över, H. (2014). No association between the functional cannabinoid receptor type 2 Q63R variants and inflammatory bowel disease in Turkish subjects. Turkish Journal of Gastroenterology, 25(6), 639–643. https://doi.org/10.5152/tjg.2014.6568
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Abstract

Abstract Background/Aims: The endocannabinoid system can exert beneficial effects on gastrointestinal inflammation, and cannabinoid receptor-2 (CB2) agonists may represent a new therapeutic approach in inflammatory bowel disease (IBD). A functional CB2 Q63R polymorphism (rs35761398) in the CNR2 gene has been shown to affect the immunomodulating properties of the CB2 receptor. We sought to investigate whether the functional CB2 Q63R polymorphism (rs35761398) is associated with IBD susceptibility in a Turkish clinical sample. Materials and Methods: A total of 202 IBD patients, comprising 101 Crohn’s disease (CD) patients and 101 ulcerative colitis (UC) patients, and 101 healthy controls were included in the study. The CB2 Q63R polymorphism was genotyped using real-time PCR. Results: There were no significant differences in the genotype frequencies of the three study groups. The odds ratio of the minor Q allele for CD relative to the common R allele was not significant (OR =1.02, 95% CI =0.67-1.56, p=0.99). Similarly, the odds ratio of the minor Q allele for UC relative to the common R allele did not reach statistical significance (OR =1.10, 95% CI =0.72-1.68, p=0.75). Moreover, the genotype frequencies did not show any significant association with the disease extent in either CD (p= 0.71) or UC patients (p=0.59). Conclusion: These pilot findings suggest that CB2 Q63R polymorphism does not play a major role in genetic susceptibility to IBD or in its disease phenotypes among Turkish subjects.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 25 · Issue 6
Pages 639-643
DOI 10.5152/tjg.2014.6568
History
Published Online December 15, 2014
Copyright
Copyright (c) 2014 Oya Yonal, Fatih Eren, Yusuf Yılmaz, Özlen Atuğ, Hülya Hamzaoğlu Över
Affiliations
Oya Yonal
Department of Gastroenterology, Marmara University Faculty of Medicine, İstanbul, Turkey
Fatih Eren
Department of Marmara University Institute of Gastroenterology, İstanbul
Yusuf Yılmaz
Department of Gastroenterology, Marmara University Faculty of Medicine, İstanbul, Turkey; Marmara University Gastroenterology Institute, İstanbul, Turkey
Özlen Atuğ
Department of Gastroenterology, Marmara University, School of Medicine, İstanbul
Hülya Hamzaoğlu Över
Department of Gastroenterology, Marmara University Faculty of Medicine, İstanbul, Turkey
Cite this Article
Yonal, O., Eren, F., Yılmaz, Y., Atuğ, Özlen, & Hamzaoğlu Över, H. (2014). No association between the functional cannabinoid receptor type 2 Q63R variants and inflammatory bowel disease in Turkish subjects. Turkish Journal of Gastroenterology, 25(6), 639–643. https://doi.org/10.5152/tjg.2014.6568
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