Published In
Turkish Journal of Gastroenterology
Volume 25 · Issue 2
Pages: 133-140
History
Published Online: April 15, 2014
Copyright © 2014 Venkatanarayana Gangarapu, Kemal Yıldız, Ali Tüzün İnce, Birol Baysal
Venkatanarayana Gangarapu
Department of Gastroenterology, Bezmialem Vakif University, İstanbul, Turkey
Kemal Yıldız
Department of Gastroenterology, Bezmialem Vakif University Faculty of Medicine, İstanbul, Turkey
Ali Tüzün İnce
Department of Gastroenterology, Bezmialem Vakıf University Faculty of Medicine, İstanbul, Turkey
Birol Baysal
Department of Gastroenterology, Bezmialem Vakıf University, İstanbul, Turkey
Gangarapu, V., Yıldız, K., İnce, A. T., & Baysal, B. (2014). Role of gut microbiota: Obesity and NAFLD. Turkish Journal of Gastroenterology, 25(2), 133–140. https://doi.org/10.5152/tjg.2014.7886
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Abstract
Abstract Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease in developed countries. Obesity is the most important risk factor for metabolic syndrome and NAFLD. Accumulated evidence has revealed that gut microbial compositional changes may be associated with more energy harvesting from the diet, which promotes increased fatty acid uptake from adipose tissue and shifts lipid metabolism from oxidation to de novo production. Furthermore, changes in intestinal barrier function contribute to metabolic endotoxemia in the form of low-grade microbial inflammation. Persistent inflammation exacerbates NAFLD progression. In this review, we discuss the role of gut microbiota in obesity and NAFLD.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 25 · Issue 2
Pages
133-140
History
Published Online
April 15, 2014
Copyright
Copyright (c) 2014 Venkatanarayana Gangarapu, Kemal Yıldız, Ali Tüzün İnce, Birol Baysal
Affiliations
Venkatanarayana Gangarapu
Department of Gastroenterology, Bezmialem Vakif University, İstanbul, Turkey
Kemal Yıldız
Department of Gastroenterology, Bezmialem Vakif University Faculty of Medicine, İstanbul, Turkey
Ali Tüzün İnce
Department of Gastroenterology, Bezmialem Vakıf University Faculty of Medicine, İstanbul, Turkey
Birol Baysal
Department of Gastroenterology, Bezmialem Vakıf University, İstanbul, Turkey
Cite this Article
Gangarapu, V., Yıldız, K., İnce, A. T., & Baysal, B. (2014). Role of gut microbiota: Obesity and NAFLD. Turkish Journal of Gastroenterology, 25(2), 133–140. https://doi.org/10.5152/tjg.2014.7886
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