Original Article

Relationship between HER-2, COX-2, p53 and clinicopathologic features in gastric adenocarcinoma. Do these biomarkers have any prognostic significance?

Volume 25 · Issue 1 Publish Date: February 15, 2014
Nesrin Ugraş Gonca Özgün Gökhan Ocakoğlu Ömer Yerci Ersin Öztürk
Full Text PDF
DOI

Published In

Turkish Journal of Gastroenterology

Volume 25 · Issue 1

Pages: 176-181

History

Published Online: February 15, 2014

Copyright © 2014 Nesrin Ugraş, Gonca Özgün, Gökhan Ocakoğlu, Ömer Yerci, Ersin Öztürk

Nesrin Ugraş
Department of Pathology, Uludağ University Faculty of Medicine, Bursa, Turkey
Gonca Özgün
Department of Pathology, Uludağ University Faculty of Medicine, Bursa, Turkey
Gökhan Ocakoğlu
Department of Biostatistics, Uludağ University Faculty of Medicine, Bursa, Turkey
Ömer Yerci
Department of Pathology, Uludağ University Faculty of Medicine, Bursa, Turkey
Ersin Öztürk
Departments of Gastroenterology and Pathology,Uluda¤ University, School of Medicine, Bursa
Ugraş, N., Özgün, G., Ocakoğlu, G., Yerci, Ömer, & Öztürk, E. (2014). Relationship between HER-2, COX-2, p53 and clinicopathologic features in gastric adenocarcinoma. Do these biomarkers have any prognostic significance?. Turkish Journal of Gastroenterology, 25(1), 176–181. https://doi.org/10.5152/tjg.2014.5280
Endnote/Zotero/Mendeley (RIS) BibTeX
Full Text Full Text PDF

Abstract

Abstract Background/Aims: The aim of this study was to examine the expression of HER-2, p53 and COX-2 in gastric adenocarcinoma and to investigate whether these markers were useful in predicting the clinicopathologic features. Materials and Methods: Primary gastric adenocarcinoma specimens were obtained from 56 patients who underwent total/subtotal gastrectomy with extended lymphadenectomy between December 2011 – December 2012. We investigated the association between the expression of these markers and clinicopathologic factors by immunohistochemistry. Results: COX-2 positive cases were detected in 28 (50%) of the 56 patients and COX-2 expression was significantly correlated with presence of perineural invasion (p=0,032). 37 cases (66.1%) were defined positive for p53. The expression of p53 was significantly correlated with increasing age (p=0,003), but there was no correlation with other clinicopathological variables. Among the 56 primary gastric cancers, 9 (16.1%) cases showed intermediate (2+) positive expression and 7 (12.5%) cases showed (3+) positive expression for HER-2. No significant correlations were determined between HER-2 and the other variables. Conclusion: Although, this study failed to show any relationship between HER-2 and clinicopathological factors, but our results demondtrated that COX-2 expression might serve as a powerful indicator for estimating perineural invasion, which is an independent worse prognostic factor for survival in gastric adenocarcinoma. Additionally, detecting the expression of p53 can assist with the treatment options for elderly patients with gastric adenocarcinoma. A better understanding of HER-2, COX-2 and p53 expression in gastric adenocarcinoma may improve the staging strategies and influence new treatment modalities.

Most read articles by the same author(s)

1 2 > >> 
Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 25 · Issue 1
Pages 176-181
DOI 10.5152/tjg.2014.5280
History
Published Online February 15, 2014
Copyright
Copyright (c) 2014 Nesrin Ugraş, Gonca Özgün, Gökhan Ocakoğlu, Ömer Yerci, Ersin Öztürk
Affiliations
Nesrin Ugraş
Department of Pathology, Uludağ University Faculty of Medicine, Bursa, Turkey
Gonca Özgün
Department of Pathology, Uludağ University Faculty of Medicine, Bursa, Turkey
Gökhan Ocakoğlu
Department of Biostatistics, Uludağ University Faculty of Medicine, Bursa, Turkey
Ömer Yerci
Department of Pathology, Uludağ University Faculty of Medicine, Bursa, Turkey
Ersin Öztürk
Departments of Gastroenterology and Pathology,Uluda¤ University, School of Medicine, Bursa
Cite this Article
Ugraş, N., Özgün, G., Ocakoğlu, G., Yerci, Ömer, & Öztürk, E. (2014). Relationship between HER-2, COX-2, p53 and clinicopathologic features in gastric adenocarcinoma. Do these biomarkers have any prognostic significance?. Turkish Journal of Gastroenterology, 25(1), 176–181. https://doi.org/10.5152/tjg.2014.5280
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX
Outlines