Original Article

Is gastroesophageal reflux contribute to the development chronic cough by triggering pulmonary fibrosis

Volume 25 · Issue 1 Publish Date: February 15, 2014
Oğuzhan Aksu Necla Songür Yıldıran Songür Önder Öztürk Ali Kudret Adiloğlu Nilgün Kapucuoğlu Mete Akın
Full Text PDF
DOI

Published In

Turkish Journal of Gastroenterology

Volume 25 · Issue 1

Pages: 48-53

History

Published Online: February 15, 2014

Copyright © 2014 Oğuzhan Aksu, Necla Songür, Yıldıran Songür, Önder Öztürk, Ali Kudret Adiloğlu, Nilgün Kapucuoğlu, Mete Akın

Oğuzhan Aksu
Department of Internal Medicine, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey
Necla Songür
Department of Chest Disease, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey
Yıldıran Songür
Türkiye Yüksek İhtisas Hastanesi, Gastroenteroloji Kliniği, Ankara
Önder Öztürk
Department of Chest Disease, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey
Ali Kudret Adiloğlu
Department of Microbiology, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey
Nilgün Kapucuoğlu
Departments of Pathology, Süleyman Demirel University, School of Medicine, Isparta
Mete Akın
Department of Gastroenterology, Suleyman Demirel University, School of Medicine, Isparta
Aksu, O., Songür, N., Songür, Y., Öztürk, Önder, Adiloğlu, A. K., Kapucuoğlu, N., & Akın, M. (2014). Is gastroesophageal reflux contribute to the development chronic cough by triggering pulmonary fibrosis. Turkish Journal of Gastroenterology, 25(1), 48–53. https://doi.org/10.5152/tjg.2014.4018
Endnote/Zotero/Mendeley (RIS) BibTeX
Full Text Full Text PDF

Abstract

Abstract Background/Aims: Previous studies have shown that the prevalence of abnormal acid reflux in fibrotic lung disease patients is high, and in particular, patients with secondary pulmonary fibrosis show higher esophageal acid exposure than normal controls. There are also some findings that, in patients with pathological reflux, pulmonary fibrosis may develop. The aim of this study is to investigate if pulmonary fibrosis is involved in the pathogenesis of chronic cough due to Gastroesophageal Reflux. Materials and Methods: A prospective study was performed in twenty-one patients with chronic cough due to gastroesophageal reflux who was diagnosed as reflux esophagitis by upper gastrointestinal endoscopy, histology, and in ten healthy controls without GER or any lung disease. All participitants underwent laryngoscopic examination and gastroesophageal scintigraphy with late lung imaging. Bronchoalveolar lavage fluid total and differential cell counts, T and B cell subsets, and the concentrations of IL- 1β and TNF-α were measured. Results: Reflux extending into the proximal esophagus was noted in 52.5%, and posterior laryngitis was present in 90.5% of the patients. No evidence of pulmonary aspiration was noted in the patients with reflux on scintigraphic examination. No significant difference was found between the GER and control groups in terms of cellular content, IL-1β and TNF-α levels or mean T cell subsets and B cell counts in bronchoalveolar lavage fluid. Forced expiratory volume in one second, forced vital capacity FEV1/FVC, total lung capacity, and carbon monoxide diffusion capacity values were within normal limits in the gastroesophageal reflux group. Conclusion: Our findings do not support the hypothesis that gastroesophageal reflux leads to chronic cough by triggering alveolar epithelial injury and subsequent pulmonary fibrosis.

Most read articles by the same author(s)

1 2 > >> 
Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 25 · Issue 1
Pages 48-53
DOI 10.5152/tjg.2014.4018
History
Published Online February 15, 2014
Copyright
Copyright (c) 2014 Oğuzhan Aksu, Necla Songür, Yıldıran Songür, Önder Öztürk, Ali Kudret Adiloğlu, Nilgün Kapucuoğlu, Mete Akın
Affiliations
Oğuzhan Aksu
Department of Internal Medicine, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey
Necla Songür
Department of Chest Disease, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey
Yıldıran Songür
Türkiye Yüksek İhtisas Hastanesi, Gastroenteroloji Kliniği, Ankara
Önder Öztürk
Department of Chest Disease, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey
Ali Kudret Adiloğlu
Department of Microbiology, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey
Nilgün Kapucuoğlu
Departments of Pathology, Süleyman Demirel University, School of Medicine, Isparta
Mete Akın
Department of Gastroenterology, Suleyman Demirel University, School of Medicine, Isparta
Cite this Article
Aksu, O., Songür, N., Songür, Y., Öztürk, Önder, Adiloğlu, A. K., Kapucuoğlu, N., & Akın, M. (2014). Is gastroesophageal reflux contribute to the development chronic cough by triggering pulmonary fibrosis. Turkish Journal of Gastroenterology, 25(1), 48–53. https://doi.org/10.5152/tjg.2014.4018
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX
Outlines