ISSN 1300-4948 | E-ISSN 2148-5607
Gastrointestinal Tract - Original Article
How would serum 25(OH)D level change in patients with inflammatory bowel disease depending on intestinal mucosa vitamin D receptor (VDR) and vitamin D1-α hydroxylase (CYP27B1)?
1 Department of Gastroenterology, Huashan Hospital Affiliated to Fudan University, Shanghai, China  
Turk J Gastroenterol ; : -
DOI: 10.5152/tjg.2018.17828
Key Words: Inflammatory bowel disease, Vitamin D, vitamin D, vitamin D receptor, vitamin D1-α hydroxylase
Abstract

Background/Aims: To investigate how the serum 25-hydroxyvitamin D (25(OH)D) level change in patients with inflammatory bowel disease (IBD) and investigate the intestinal mucosa vitamin D receptor (VDR) and vitamin D1-α hydroxylase (CYP27B1) expressions.


Materials and Methods
: A total of 105 patients with IBD were enrolled in the present study, including 49 cases with ulcerative colitis (UC) and 56 cases with Crohn’s disease (CD), compared with 45 healthy controls (CON) during the same period by testing the permeability of the intestinal mucosa. The expressions of VDR and CYP27B1 in the intestinal mucosa were detected, so as the serum endotoxin, tumor necrosis factor (TNF)-α, and 25(OH)D levels.


Results
: The lactulose and mannitol absorption ratio (LMR) and serum endotoxin and TNF-α levels were significantly higher in the IBD group than in the CON group (p<0.05). The levels of LMR, endotoxin, and TNF-α were higher in the UC group than in the CD group, but 25(OH)D was lower (p<0.05). VDR in the IBD and UC groups was down-regulated when compared with the CON group (p<0.05), but there was no significance between them (p>0.05). CYP27B1 in the IBD and CD groups was significantly up-regulated compared with the CON group (p<0.05), with no significant difference between them (p>0.05).


Conclusion
: Patients with IBD exhibit vitamin D metabolism imbalance, lower serum 25(OH)D, and lower VDR expression, but higher CYP27B1 expression in the colonic mucosa. However, VDR and CYP27B1 cannot be used to distinguish UC and CD.


Cite this article as
: Huang J, Chen T, Liu Y, Lyu L, Li X, Yue W. How would serum 25(OH)D level change in patients with inflammatory bowel disease depending on intestinal mucosa vitamin D receptor (VDR) and vitamin D1-α hydroxylase (CYP27B1)? Turk J Gastroenterol DOI: 10.5152/tjg.2018.17828

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AVES | Copyright © 2018 Turkish Society of Gastroenterology | Latest Update: 22.10.2018