ISSN 1300-4948 | E-ISSN 2148-5607
Pediatric Gastroenterology - Original Article
Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?
1 Department of Pediatric Gastroenterology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey  
2 Department of Pediatris, Erzurum Regional Training and Research Hospital, Erzurum, Turkey  
3 Department of Pediatric Gastroenterology, Atatürk University School of Medicine, Erzurum, Turkey  
4 Department of Biochemistry, Atatürk University School of Medicine, Erzurum, Turkey  
5 Department of Pediatric Endocrinology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey  
Turk J Gastroenterol 2018; 29: 215-220
DOI: 10.5152/tjg.2018.17451
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Key Words: Celiac disease, bone density, vitamin K
Abstract

Background/Aims: To investigate bone mineral density (BMD) in children with celiac disease (CD) and to evaluate the association between vitamin K levels and osteoporosis.

 

Materials and Methods: Children with CD and age- and sex-matched healthy control subjects were prospectively included in the study. BMD was measured, and serum anti-tissue transglutaminase IgA, ferritin, folate, vitamin B12, 25-hydroxy vitamin D and K2, calcium, phosphate, alkaline phosphatase, and parathormone were assayed in all subjects.

 

Results: Overall, 72 patients (mean age 11.69±3 years, 59.7% female) and 30 healthy subjects (mean age 12.27±2.12 years, 63.3% female) were enrolled. The mean BMD Z score of the celiac group was significantly lower than that of the control group (−1.23±1.07 vs. −0.35±1.04, p=0.001). Vitamin D and K2 values did not differ significantly between the two groups (p>0.05). BMD was positively correlated with vitamin D (r=0.198, p=0.001) and negatively with PTH (r=−0.397, p=0.002).

 

Conclusion: The BMD of celiac patients was lower than that of the control subjects. There was no difference in terms of vitamin D and K2 levels between the two groups. Further studies investigating the level and effect of vitamin K on bone in CD are needed.

 

 

 

Cite this article as: Volkan B, Fettah A, İşlek A, Kara SS, Kurt N, Çayır A. Bone mineral density and vitamin K status in children with celiac disease: is there a relation? Turk J Gastroenterol 2018; 29: 215-20.

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